Prototypr Drug Unit 6- Losartan

Question 1

Therapeutic classification

Answer 1

Antihypertensive

Question 2

Pharmacologic classification

Answer 2

Angiotensin 2 receptor blocker

Question 3

Therapeutic effects and uses

Answer 3

Used for the treatment of hypertension, stroke, and the prevention of type 2 diabetic nephropahypertrophy.

Question 4

Mechanism of action

Answer 4

Block angiotensin AT1 receptors which causes blood pressure to decline. (Reduces blood volume which is because of vasodilation)

Question 5

Adverse effects

Answer 5

Headache, dizziness, orthostatic hypotension, fatigue, diarrhea, upper respiratory infection

Question 6

Black box warning

Answer 6

Fetal injury death may occur

Question 7

Contraindications

Answer 7

Hypersensitivity
Pregnancy and lactation
Kidney or liver probs
Hypokalemia

Question 8

Drug interactions

Answer 8

NSAIDs= decrease antihypertensive activity
Potassium and potassium-soaring diuretics= hyperkalemia
Diuretic and antihypertensives= additive hypotension
Alcohol= additive hypotension
Lithium= levels can get increased

Question 9

Herbal/food interactions

Answer 9

Hawthorn= additive hypotension

Question 10

Treatment of overdose

Answer 10

Normal saline or a vasopressor