Prototype Drug Unit 8 & 9- Glyburide Flashcards

1
Q

Classification

A

Antidiabetic drug

Sulfonylurea

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2
Q

What is it used for

A

Lowering blood glucose levels in patients with type 2 diabetes

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3
Q

How does it work?

A

Stimulates the release of insulin from pancreatic beta cells and increases the sensitivity of peripheral tissues to insulin

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4
Q

Adverse effects

A

Hypoglycemia (too much medications or not eating enough food)
weight gain, hypersensitivity, GI distress, and hepatotoxicity

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5
Q

Contraindications

A

sensitivity to sulfa drugs or thiazide diuretics

Type 1 diabetes (Diabetic coma, DKA)

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6
Q

Drug interactions

A

Alcohol can cause hypo or hyperglycemia
nausea, vomiting, flushing, and palpitations
Anticoagulants, MAOIs, probenecid, sulfonamides, chloramphenicol, osyphenbutazone, phenylbutazone, salicylates, and clofibrate = increases hypoglycemia
Thiazides and rifampin= increased hyperglycemia

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7
Q

Herbal/Food interactions

A

Ginseng, garlic, black cohosh,juniper berries, fenurgreek, coriander, or dandelion root= hypoglycemia

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8
Q

Treatment of overdose

A

Glucose (Dextrose)

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