Prototype Drug Unit 3 & 4- Testosterone Flashcards

1
Q

Therapeutic classification

A

Male sex hormone

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2
Q

Pharmacologic classification

A

Androgen, anabolic steroid, antineoplastic

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3
Q

Therapeutic effects and uses

A

Treat delayed puberty and hypogonadism by promoting virilization, including maturation of the sexual organs, growth of facial hair, and a deepening of the voice.
In adults it is used to increase masculine features and libido.

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4
Q

Mechanism of action

A

Binds to specific receptors located in the cell cytoplasm. It then acts on the DNA to promote the synthesis of specific messenger RNA molecules.

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5
Q

Routes

A

Buccal, Transdermal, IM

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6
Q

Absorption

A

Cypionate and enanthate are slowly absorbed from IM sites

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7
Q

Distribution

A

98% bound to sex hormone-binding globulin; unknown if secreted in breast milk

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8
Q

Metabolism

A

Hepatic

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9
Q

Excretion

A

90% Renal;6% feces

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10
Q

Adverse effects

A

Decreased or increased libido. Salt and water are retained causing edema, and a diuretic may by indicated. Acne and skin irritation.

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11
Q

Black Box Warning

A

Virilization in children and women may occur following secondary exposure. Children and women should avoid the application sites in men using testosterone gel.

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12
Q

Contraindications/precautions

A

Contraindications: Men with known or suspected breast or prostatic carcinomas. Women who are or may become pregnant. Prostatic hyperplasia

Precautions: Preexisting renal or hepatic impairment. patients with diabetes mellitus, myocardial infarcion, coronary artery disease, benign prostatic hyperplasia, and acute intermittent porphyria.

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13
Q

Drug interactions

A

Increase of severe bleeding if taken with oral anticoagulants. Corticosteroids may cause additive edema. Hepatotoxic drugs can cause additive liver damage.

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14
Q

Herbal/food interactions

A

Insulin requirements may decrease, and the risk of hepatotoxicity may increase when used with echinacea.

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15
Q

Pregnancy Category

A

X

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