Week 3 Adipose Tissue Dysfunction Flashcards Preview

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Flashcards in Week 3 Adipose Tissue Dysfunction Deck (42):
1

how does adipose tissue appear under a microscope?

thin walled empty vacuole with nucleus pushed to periphery of cell (appear empty becuase stain is hydrophobic and dissolved the fat)

2

what is brown fat?

fat that is important in heat production thermogenesis

3

where/in who do we see brown fat?

newborns have quite a bit of brown fat, amount decreases with age and remains only around kidney, large vessels, neck and back at older age

4

how does brown adipose tissue appear under a micrsocope?

smaller, more numerous fat vacuoles within each adipocyte (than white adipose tissue)

5

describe the vascularity and innervation of brown adipose tissue?

highly vascular and innervated

6

what is metabolic syndrome?

A cluster of conditions (high BP, high cholesterol, hyperglycemia, high visceral fat) that occur together, increasing your risk of heart disease, diabetes, and stroke

7

what is visceral obesity?

fat surrounding organs

8

what does adpiose tissue consist of?

macrophages, adipocytes, fibroblasts, pre-adipocytes

9

what is role of fibroblasts?

make ECM and collagen

10

what is role of pre-adipocytes?

stemm cell-like that generate new adipose cells

11

what is role of macrophages?

seen mostly in visceral adipose, recruited to adipocytes as they grow larger, increase inflammation and decrease adiponectin

12

what is the role of white adipose tissue?3

insulate body, store and release FFAs, protect organs

13

what is role of lipoproteins such as chylomicrons?

transport triglycerides from intestines to adipose tissue

14

what is role of lipoprotein lipase?

separates TGs from lipoproteins so they can be stored in adipocytes

15

what is role of hormone sensitive lipase?

liberates FFAs from adipocytes to increase FFAs in bloods

16

what effect does insulin have on LPL and HSL

promotes LPL and inhibits HSL (promotes TG sotrage)

17

why do individuals with type II diabetes get fatter?

increased insulin levels increases the amount of TG stored in adipocytes (LPL increases and HSL decreases)

18

what are adipokines?

the endocrine hormones of adipocytes

19

in general, as adipose volume increases, what occurs to adipokine levels?

increase as well (except for adiponectin!)

20

Leptin: main site of production, role 2, stimulated by

mainly produced in SubQ adipocytes, increases lipid oxidation in liver and lipolysis in muscle and adipose tissue (fat burner)
stim by FFAs and insulin

21

Adiponectin: role 3

anti-atherosclerotic, enhances insulin sensitivity, increases glucose uptake

22

when is adiponectin synthesis/activity reduced?3

obesity, insulin resistance, metabolic syndrome

23

what is the role of IL-6? where is it produced

recruits macrophages to adipose tissue, visceral adipocytes

24

which hormones are primarily produced in visceral adipose 2

angiotensinogen, IL-6

25

where is leptin primarily produced

SubQ adipose

26

are macrophages more prevelant in visceral or SubQ adipose?

visceral

27

what is the signaling between adipocytes and macrophages

large adipocytes release FFAs-->macrophages releases TNF-alpha-->adipocytes induce lipolysis and express IL-6-->more macrophages are recruited-->inflamation seen in obesity occurs (adipose tissue dysfunction)

28

obesity is associated with what form of inflammation? attributed to?

a chronic low grade inflammatory state. attributed to increased macrophages

29

what is meant by adipose tissue dysfunciton?

this denotes a state of hypersecretion of pro-atherogenic, pro-inflammatory, and pro-diabetic adipocytokines

30

who has more macrophages in their adipose tissue skinny or fat people?

fat

31

macrophage number in adipose tissue correlates with...

insulin resistance

32

how does insulin resistance occur in obese people?

the viscous cycle of inflamation and hyper-secretion seen in adipose of fat people releases FFAs. chronically high levels of FFA inhibits insulin signaling TNF-alpha also confers insulin resistance

33

how does adiponectin increase insulin sensitivity?

trigger break down (oxidation) of FFAs in liver, inhibits glucose production

34

what causes type II diabets (2)?

insulin resistance and a decreased insulin secretoty fxn of pancreatic beta-cells

35

why is there increased insulin in fat people?

more insulin is made due to hyper-nutrition and insulin resistance...if this compensatory mechanism is exceeded type II diabetes occurs

36

low adiponectin, and high IL-6, TNF-a, and leptin are associated with an increased risk of...

type II diabetes

37

increased angioteninogen leads to what in obese people? (produced by dysfunctional adipocytes)

high blood pressure

38

what is one explanation for the atherosclerosis seen in obese people?

a decrease in adiponectin

39

low levels of which hormone is an independent predictor of future vascular disease?

adiponectin

40

which hormone is a good measure of adipocyte dysfunction? why

adiponectin because it is only produced by adipocytes

41

define independent risk factor

something is a significant contributor to a disease state

42

what are the benefits of exercise in obese people?

reduce adipocyte size and modify adipocyte dysfunciton (decrease IL-6, TNF-alpha, leptin and increase adiponectin levles)

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