Week 4 sER Module Flashcards Preview

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Flashcards in Week 4 sER Module Deck (7)
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1

what is the structural difference between sER and rER

smooth ER lacks attached ribosomes.

2

what is the role of sER?3

1. synthesize lipids (FAs, phsopholipids, steroid hormones)
2. store calcium
3. contains detoxifying enzymes

3

what is the role of the sER in the cells of the adrenal cortex?

produce steroid hormones

4

what is the role of sER in skeletal muscle cells?

sER is called the sarcoplasmic reticulum. sER sequesters the calcium needed for muscle contraction. Calcium released in response to T-tubule signaling (depolarization)

5

what is the role of sER in hepatocytes?

sER contains a variety of detoxifying enzymes anchored in the sER membrane (Cytochrome P450)

6

what alterations/modifications does the detoxifying enzymes of liver cells make?

make hydrophobic compounds hydrophilic so they can be excreted.

7

what two compounds/drugs are detoxified in the sER of the liver? (high yield)

ethanol and barbiturates

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