Week 4 sER Module Flashcards Preview

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Flashcards in Week 4 sER Module Deck (7)
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1
Q

what is the structural difference between sER and rER

A

smooth ER lacks attached ribosomes.

2
Q

what is the role of sER?3

A
  1. synthesize lipids (FAs, phsopholipids, steroid hormones)
  2. store calcium
  3. contains detoxifying enzymes
3
Q

what is the role of the sER in the cells of the adrenal cortex?

A

produce steroid hormones

4
Q

what is the role of sER in skeletal muscle cells?

A

sER is called the sarcoplasmic reticulum. sER sequesters the calcium needed for muscle contraction. Calcium released in response to T-tubule signaling (depolarization)

5
Q

what is the role of sER in hepatocytes?

A

sER contains a variety of detoxifying enzymes anchored in the sER membrane (Cytochrome P450)

6
Q

what alterations/modifications does the detoxifying enzymes of liver cells make?

A

make hydrophobic compounds hydrophilic so they can be excreted.

7
Q

what two compounds/drugs are detoxified in the sER of the liver? (high yield)

A

ethanol and barbiturates

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