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Flashcards in Week 5 Mitochondrial damage Deck (5)
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1

what (in general) decreases (2) and increases (1) in mitochondria exposed to hypoxia?

decrease: Oxygen, ATP
increase: protons (becomes more acidic due to lactate buildup)

2

what are the effects of decreased ATP in hypoxic/ischemic condiitions? how? (2)

Sodium accumulates in the cell and water follows (cell swells). Na/K ATPase quits (increases Na) and the Na/H pump increases to remove protons which increases the amount of Na in the cell further.

3

what is hydropic change

the phenomenon that results from decreased ATP in cells (hypoxia) and an increased influx of water and Na that causes the cell to swell

4

what follows hydropic change in ischemic cells?

Ca induced injury

5

what effect does increased intracellular Ca have on ischemic cells

activates phospholipases, proteases, endonucleases that degrade cell components and cause apoptosis/necrosis

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