114 - Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Question 1

What are the three antithrombotic drug groups?

Answer 1

Antiplatelet
Anticoagulants
Antifibrinolytic

Question 2

Antiplatelet drugs are used mostly in ___ thrombi

Answer 2

Arterial

Question 3

Anticoagulant drugs are used for prevention and treatment of ____ thromboembolism. This is because __ is a main component in the venous thrombi

Answer 3

venous

fibrin

Question 4

Antifibrinolytic are used for specific cases of ___ thromboembolism such as ___

Answer 4

venous

massive PE

Question 5

Normally ___ and ___ from the endothelial cells keep platelets in the ___ state

Answer 5

NO
prostacyclin
inactive

Question 6

Damaged blood vessel reveal ___ which than binds to factor __ and activates the coagulation cascade

Answer 6

TF

7a

Question 7

Aspirin mechanism is based on an ___ inhibition of ___, which is a critical enzyme in the biosynthesis of thromboxane A2. When given in high dosage it can also inhibit ___ which is found in inflammation and endothelial cells.

Answer 7

irreversible
COX1
COX2

Question 8

Aspirin is indicated for ___ prevention of CV events in patients with coronary/cerebral/peripheral disease. It is not recommended for ___ prevention

Answer 8

secondary

primary

Question 9

Aspirin’s most common s/e is ___ related and is ___ depended. Other s/e include ___, ___ (may cause bronchospasm), ___ to the liver and kidneys in overdose

Answer 9

GI
dosage 
bleeding
allergy
toxicity

Question 10

What are the 3 ADP receptor antagonist?

Answer 10

Thienopyridines (Clopidogrel, Prasugrel)
Ticagrelor
Cangrelor

Question 11

Thienopyridines (Clopidogrel) are selective ___ aggregation which is ___ mediated. It is done by an irreversible blockage of ___

Answer 11

platelets
ADP
P2Y12

Question 12

What is the commercial name of clopidogrel and prasugrel?

Answer 12

Plavix

effient

Question 13

Effient is __ times more potent than __

Answer 13

10

Plavix

Question 14

Clopidogrel and ___ combination for __ weeks is recommended post ___ implantation , and for ___ months post ___ implantation

Answer 14

aspirin
stent
6
DES

Question 15

___ and aspirin is also useful for ___

Answer 15

Clopidogrel

unstable angina

Question 16

Prasugrel is used in patients scheduled to go through __.

Answer 16

PCI

Question 17

Prasugrel is contraindicated in patients with a history of ___

Answer 17

Cerebrovascular disease

Question 18

Prasugrel should be avoided in patients over the age of ___, or with history of ___/___ .

Answer 18

75
stroke
TIA

Question 19

Prasugrel should be stopped ___ before a big surgery. If bleeding occurs- ___ supplement may help. Rare s/e include: neutropenia, ___, and ___

Answer 19

5-7
platelets
thrombocytopenia
TTP

Question 20

What is the commercial name of ticagrelor? What is its mechanism? It is ___ for ACS patients more than ___ especially high risk patients.

Answer 20

Brilinta
Reversible P2Y12 inhibitor
recommended
clopidogrel

Question 21

GP IIB/IIIA receptor antagonists drugs are used for __ patients and include the following drugs: (3)

Answer 21

ACS
Tirofiban
Abciximab
eptifibatide

Question 22

Mechanism

Answer 22

aaa