155 - Pertussis and Other Bordetella Infections Flashcards
Which pathogen causes pertusis?
Bordetella
Bordetella pertussis is a G(_) and __
+
aerobic
What is the virulent factor of pertussis?
pertussis toxin
Pertussis pneumonia occurs in _% of all infected babies, leading to a __ disease.
10
bilateral
Catarrhal phase occurs after - days of incubation, and present with cold symptoms: 4. This period lasts for 1-2 weeks.
7-10 rhinitis tearing mild cough low grade fever malaise
Paroxysmal phase is when the __ becomes more __ and __ with recurrent attacks of 5-10 coughs. - _ are common with mucous plug that might get coughed out.
coughs
frequent
spastic
post tussive vomiting
In the paroxysmal phase, audible __ may appear. __ disturbance is common due frequent episodes during the night. This phase lasts for - weeks. Most of the __ occurs in this phase. __ is uncommon
whoop sleep 2-4 complications fever
Convalescent phase is last. Coughs become __ frequent. This phase lasts for - months.
less
1-3
The best predictors to diagnose pertussis are: 4
post tussive vomiting
night coughing
sweating between episodes
prior exposure to diagnosed patients
Complications are more common in __, and may include: 4
babies subconjunctiva bleedings hernia pneumothorax facial/truncal petechiae
What is the gold standard for pertussis diagnosis?
nasopharynx mucus culture
__ may substitute the gold standard in pertussis diagnosis. Another option is to follow __ for patients
who are symptomatic for >_ weeks
PCR
serology
4
What is the drug of choice to eradicate pertussis from the nasopharynx
macrolides
if sensitive- TMX-SMX
__ treatment and hospitalization is recommended for all __ and patients with severe case.
supportive
babies
The best preventive care is- __. In developing countries- __, in developed countries- __
vaccination
whole cell pertussis
acellular
