179 - Leptospirosis Flashcards

1
Q

Leptospirosis is usually ___ or with light __, __ and __.

A

asymptomatic
fever
headache
myalgia

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2
Q

Severe leptospirosis present with __, __, and __ (mostly __)

A

jaundice
renal failure
bleeding
pulmonary

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3
Q

Leptospirosis transmission is via direct contact with __, __, __, __.

A

urine
blood
tissue
water reservoir

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4
Q

Leptospirosis penetrate to the body through __/__ and the spreads is __.

A

skin cracks/mucosa

hematogenic

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5
Q

Leptospirosis incubation is between - weeks and up to __ days, then the bacteria can be found in __->__->__

A
1-2
30
blood
CSF
urine
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6
Q

Mild leptospirosis symptoms include __ signs. May look like ___ due to __ and other symptoms

A

flu-like
aseptic meningitis
photophobia

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7
Q

Physical examination may show: 5

A
conjunctiva erythema
hepatosplenomegaly
jaundice
lymphadenopathy
rash
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8
Q

Mild leptospirosis usually resolves __ within - days.

A

spontaneously

7-10

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9
Q

Severe leptospirosis typical presentation is called- __

A

Weil’s syndrome

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10
Q

Weil’s syndrome triade:

A

jaundice
hemorrhage
acute kidney injury

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11
Q

Leptospiral meningitis includes ___ status changes, and has up to __% chance for mortality if left untreated.

A

mental

13

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12
Q

Mortality due to leptospirosis is usually caused by __ and __ or complications due to __ originating in the GI/urinary/cutaneous/pulmonary system.

A

septic shock
MOF
hemorrhage

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13
Q

Leptospirosis lab is usually unspecific, but can show __ due to __ consumption. Inflammatory index increase (__, __, __)

A

thrombocytopenia
platelets
CRP/ESR/procalcitonin

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14
Q

What are the electrolyte and liver changes in leptospirosis?

A
hypokalemia 
elevated Cr
elevated urea
elevated bilirubin
elevated transaminase/ALP/amylase
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15
Q

Leptospirosis urine will show: 5

A
leukocytes
erythrocytes
hyaline cast 
granular casts
protein
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16
Q

Leptospirosis CSF will show: 5

A

pleocytosis

PMN dominance followed by lymphocytes dominance

17
Q

In pulmonary involvement the CXr will show a bilateral __ image, resembling diffused alveolar __, mostly in the __ lobes. Severe cases may show __ image.

A

patchy
hemorrhage
lower
ground glass

18
Q

Definitive diagnosis is done with __

A

PCR

19
Q

Leptospirosis infection has 2 phases: __ and __

A

acute

immune

20
Q

Severe leptospirosis should be treated with __/ __/ __

A

penicillin G / cephalosporines (ceftriaxone/cefotaxime) / doxycycline

21
Q

Mild leptospirosis should be treated with PO __/__/__/__

A

doxycycline/ azithromycin/ ampicillin/ amoxicillin

22
Q

In rare cases, when treating leptospirosis, __ reaction may occur

A

Jarisch Herxheimer

23
Q

Beside ABx, when treating leptospirosis, consider adequate __ treatment depending on the __ function.

A

supportive

renal