297 - Sepsis and Septic Shock Flashcards
Define sepsis=__
A life-threatening organ dysfunction caused by a dysregulated host response to infection
Define septic shock=__
A subset of sepsis in which underlying circulatory
and cellular/metabolic abnormalities lead to substantially increased mortality risk
What are the most common causes of sepsis?
pneumonia
intraabdominal infections
UTI
What are the risk factors for sepsis? 4
HIV
immunosuppression
COPD
cancer
In order to identify septic shock look for ___ signs: 4
hypoperfusion oliguria mental status changes reduced perfusion to periphery increased lactate
What are the three organ failure common in septic shock?
cardiorespiratory
renal
neurological
Name a common presentation of a cardiorespiratory disorder in septic shock:
ARDS- hypoxemia with bilateral pulmonary infiltrations from a non cardiac source, appearing 7 days after infection.
Name a common presentation of a renal disorder in septic shock:
AKI- in 50% of septic shock- increases the risk for death by 6-8 times
What may be the treatment for AKI due to septic shock?
dialysis
Name two common presentation of a neurological disorder in septic shock:
coma
delirium
Quick SOFA= 1-3points:
1-__
2-__
3-__
- systolic BP<100, tachypnea>22, mental status changes
- sepsis, vasopressors required to keep MAP
- serum lactate>2mmol/L after fluid resuscitation
What are the main SOFA variables? 6
systolic BP<100 serum Cr >1.2 PaO2/FiO2 <=300 platelets <= 150 GCS <15 bilirubin >1.2
What are the primary steps when treating sepsis? 4
It should be done in the first _ hours.
diagnosis->cultures->empiric Abx->lactate levels
3
What should the follow-up sepsis treatment include? 4
fluids (bolus)
vasopressors
lactate levels
ICU
