203 - Rabies (other rhabdovirus infections – not included) Flashcards
Incubation period lasts - days.
20-90
Rabies virus infects __ cells.
nerve
Once rabies virus reaches the CNS- centrifugal spread starts, along the sensory/autonomic nerves- to __, __, __, __.
saliva gland
heart
adrenal
skin
The main pathological characteristic in rabies is __ body.
Negri body
Clinical presentation usually consist of atypical __ with preserved ___. A minority of patients will present acute __.
encephalitis
consciousness
flaccid paralysis
Prodrome includes-3
pain/pruritus around the site if exposure
paresthesia
non specific signs (fever/lethargy/headache/nausea)
What are the two neurological presentations of rabies?
encephalitic (furious)- 80%
paralytic 20%
In encephalitic rabies, ___, __, __, ___ and other automimic dysfunction signs may be present.
excessive drooling
goose pimples
cardiac arrhythmia
priapism
Another classic signs of encephalitic rabies include __ and __. The combination of the two together with excessive drooling gives rise to __.
hydrophobia
aerophobia
mouth foaming
Diagnosis is made with specific __ in the __, __, or __.
antibodies
CSF
PCR
DFA (direct fluorescent antibody)
Most patients will _ if not __ in time and treated.
die
diagnosed
Most patients will die several days after __ signs appear.
clinical
Prevention is made with __ wound treatment and __+__ vaccine.
local
passive
active
PEP- __
Post-exposure prophylaxis
Rabies vaccine should be given directly to the __ and __.
wound
IM
