category X teratogen Flashcards Preview

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Flashcards in category X teratogen Deck (7)
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1

Methotrexate: inhibit folate metabolism

neural tube defects
use: cancer drug, inflammatory disease (SLE, psoriasis, RA), ectopic pregnancy

2

Statin: inhibit cholesterol synthesis (steroid hormones)

CNS + limb

3

Warfarin: anticoagulant
USE HEPARIN - DOESN'T CROSS PLACENTA

facial + limb + CNS
spontaneous abortion

4

Isotretinoin: Vit A derivative

skull + CNS + heart + parathyroid + cleft palate
interfere with homeobox/HOX gene expression
spontaneous abortion

5

DES (diethylstilbestrol)

clear cell vaginal adenocarcinoma in teen/20s

6

Thalidomide: sedative, leprosy, multiple myeloma (elderly dz)

phocomelia (LIMB hypoplasia = tha-LIMB-domide)

7

category X teratogens

MTX
warfarin
statin
isotretinoin
DES
thalidomide

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