cell biology: cytoskeleton Flashcards Preview

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Flashcards in cell biology: cytoskeleton Deck (26):
1

intermediate filament found in epithelial cells (the keratin in desmosomes + hemidesmosomes)

cytokeratin

2

intermediate filament found in all Muscle cells (smooth, skeletal, heart)

desMin

3

intermediate filament found in astrocytes + schwann cells + neuroGlia

glial fibrillary acid proteins (Gfap)

4

intermediate filament in axons

neurofilaments (low, medium, high MW)

5

intermediate filament provides structural framework for the nuclear envelope + DNA

nuclear lamins: A, B, C

6

mutation in nuclear lamins can cause

muscular dystrophy
progenia: advanced cellular aging (wrinkles in kids)

7

intermediate filament found in connective tissue: fibroblasts, leukocytes, endothelium

vimentin: supports cell membrane, keeps organelles fixed in cytoplasm

8

cytokeratin stain used to identify (IF)

carcinoma

9

desmin stain used to identify (IF)

rhabdomyosarcoma
leiomyosarcoma

10

glial fibrillary acid proteins stain used to identify (IF)

glioblastoma

11

neurofilaments stain used to identify (IF)

neuroblastoma (sympathetic ganglion cells in adrenal medulla of kids)

12

nuclear lamins A, B, C stain used to identify (IF)

primitive neuroectodermal tumor

13

vimentin stain used to identify (IF)

sarcomas

14

intermediate filament role

provide structure

15

microtubule role

movement of:
cilia: respiratory tract, bronchioles, paranasal sinus, fallopian tube
flagella: sperm
mitotic spindle: duplicated chromosomes
axonal trafficking: neurons (motor neuron)

16

microfilament contains

polymers of actin

17

actin role

cellular motility:
neutrophil chemotaxis
macrophage
microvilli - brush border
activated PLTs - change shape

18

myosin role

a motor protein that moves along actins
involved in muscle contraction: muscle cells

19

coordinated ciliated contraction due to

*gap junctions* between ciliated cells

20

cilia + flagella structure: MT architecture

9+2: 9 doublets of MT, 2 MT in center
dynein links peripheral doublets causes bending of cilium via sliding of doublets

21

1° ciliary dyskinesia

immotile cilia due to dynein arm defect:
male (immotile sperm) + female infertility (fallopion tube cilia →↑ risk ectopic pregnancy)
can include triad of sx = Kartagener syndrome

22

triad from what syndrome?
bronchiectasis
recurrent sinusitis: chronic infections + productive cough
situs inversus (50% PCD cases, need cilia for organ placement)
r/o what disease?

Kartagener syndrome = 1° ciliary dyskinesia
r/o TB: cough + infertile + caseating on CXR

23

filaments that make up cytoskeleton from thinnest to thickest

microfilaments
intermediate filaments
myosin
microtubles

24

microtuble structure

cylindrical, helical array of:
heterodimer of αtubulin +ßtubulin → form protofilament
(-) end: ßtubulin
(+) end: αtubulin

25

molecular motor protein that transports cargo anterograde along microtuble (- → +)

kinesin

26

molecular motor protein that transports cargo retrograde along microtuble (+ → -)

dynein

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