play on words Flashcards

(55 cards)

1
Q

week 4 embryogenesis

A

4 chamber heart

4 limb buds

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2
Q

week 8 embryogeneis

A

8 = GAIT (fetal movement)

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3
Q

week 10 embryogenesis

A

10 = PENis (sex genitalia)

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4
Q

Drugs that act on microtubles and interfere with function: Microtubules Get Constructed Very Poorly

A

Mebendazole (anti-helminthic): hookworm, tapeworm
Griseofulvin (anti-fungus): ringworm, nail fungus
Colchicine (anti-gout = anti-inflammation): inhibit phagocyte movement
Vincristine/Vinblastine: (anti-cancer): INHIBIT polymerization of MT, thus disrupt mitotic spindles →no mitosis
Paclitaxel (anti-cancer): STABILIZE MT, can’t break down → no mitosis

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5
Q

pro-apoptotic signal in intrinsic pathway

A

BAX = die = 3 words

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6
Q

anti-apoptotic signal in intrinsic pathway

A

Bcl-2 = live = 4 words

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7
Q

Alport Syndrome

A

can’t see
can’t pee
can’t hear a high C

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8
Q

Reactive arthritis

A

can’t see
can’t pee
can’t climb a tree

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9
Q

mesodermal defects = VACTERL

A
Vertebral defects
Anal atresia
Cardiac defects
Trachea-Esophageal fistula
Renal defects
Limb defects (bone, muscle)
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10
Q

extraocular eye muscle CN’s

A

LR6SO4R3 (lateral rectus = 6, superior oblique = 4, rest = 3)

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11
Q

facial nerve branches (CN 7)

A
Ten Zebras Bit My Chin
Temporal
Zygomatic
Buccal
Marginal mandibular
Cervical
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12
Q

conditions that cause facial nerve (CN 7) palsy

A
Lovely Bella Had An STD
Lyme's disease
Bell's palsy (idiopathic)
Herpes simplex/zoster - most common
AIDS
Sarcoidosis
Tumor
Diabetes
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13
Q

conditions that cause facial nerve palsy

A
Lovely Bella Had An STD
Lyme's disease
Bell's palsy (idiopathic)
Herpes simplex/zoster - most common
AIDS
Sarcoidosis
Tumor
Diabetes
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14
Q

5 F’s of limbic system

A
feeding
fleeing
fighting
feeling - emotions
fornication (sex)
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15
Q

what causes:
urinary incontinence
dementia - reversible
ataxia - magnets on feet

A
normal pressure hydrocephalus:
Wet
Wacky
Wobbly
tx: shunt to remove excess CSF
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16
Q

most common brain tumors in adults

A
MGM Studios
Mets
Glioblastoma
Meningioma
Schwannoma
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17
Q

most common brain tumors in kids

A

Animal kingdom, Magic Kingdom, Epcot
Astrocytoma - pilocytic
Medulloblastoma
Ependymoma

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18
Q

sleep stages and EEG waves

A

BATS Drink Blood
Beta - awake (eyes open)
Alpha - awake (eyes closed)
Theta - Stage 1 NREM
Sleep spindles + K complexes - Stage 2 NREM (bruxism)
Delta - Stage 3 NREM (slow-wave sleep, sleepwalking, night terrors, bedwetting)
Beta - Stage 4 NREM (dreaming, erection, atonia)

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19
Q

symptoms of cholinergic excess

A
DUMBBELSS (leaky state)
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation of skeletal muscle (nicotinic R, somatic nerve) + CNS (nicotinic R)
Lacrimation
Sweating (sweat glands controlled by sympathetic NS, muscarinic R)
Salivation
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20
Q

anticholinergics used to treat urge incontinence

A
On The Darn Toilet
Oxybutynin
Tolterodine
Darifenacin and solifenacin
Trospium
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21
Q

symptoms of parasympathetic inhibition (anticholinergic/antimuscarinic effects of drugs)

A

Hot as a Hare: hyperpyrexia (not sweating - inhibit muscarinic R)
Red as a Beet: vasodilation - flushed
Blind as a Bat: cyloplegia (no accommodation), mydriasis
Dry as a Bone: no salvation
Mad as a Hatter: agitation, delerium (ELDERLY)
Bloated as a Toad - constipated, urinary retention
+ tachycardia

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22
Q

drugs that inhibit P450s

A
CRACK AMIGOS 
Cimetidine
Ritonavir (ALL protease inhibitors - MOA is to inhibit P450s)
Amiodarone
Ciprofloxacin
Ketoconazole
ACUTE alcohol use
Macrolides
Isoniazid
Grapefruit juice
Omeprazole
Sulfonamides
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23
Q

what causes high anion gap metabolic acidosis?

A
MUD PILES
Methanol
U
D
P
I
L
Ethylene glycol (antifreeze)
S
24
Q

drugs eliminated by zero order elimination

A

PEA - round like “0”
Phenytoin
Ethanol
Aspirin (high or toxic concentration)

25
features of tetrology of fallot
displacement of infundibular septum IHOP 1) Interventricular septal defect = VSD 2) Hypertrophy - RVH (push against stenoic valve) 3) Overriding aorta (sits over VSD) 4) Pulmonic valve stenosis (RV outflow obstruction)
26
R→L shunts
``` 5 T's Truncus arteriosus (1 vessel) Transposition of great vessels (2 vessels switched) Tricuspid atresia (3 = Tri) Tetrology of Fallot (4 defects = Tetra) (most common cause of early childhood cyanosis) Total anomalous pulmonary venous return (TAPVR) (5 letters) ```
27
signs of aortic stenosis
less blood to periphery per contraction → weak, delayed peripheral pulses SAD: Syncope or Angina or Dyspnea (need valve replaced!)
28
antiarrhythmic classes
``` Some Block Potassium Channels Some - Na (I) Block - B Blocker (II) Potassium - K (III) Channels - Ca (IV) ```
29
rotator cuff muscles
``` SItS Supraspinatous Infraspinatous teres minor Subscapularis ```
30
wrist bones
``` proximal to distal So Long To Pinky (ends with this pinky bone - ulnar), Here Comes The Thumb (ends with this thumb bone - radial) Scaphoid Lunate Triquetrum Pisiform Hamate Capitate Trapezoid Trapezium ```
31
seronegative spondyloarthropathies
``` PAIR Psoriatic arthritis Ankylosing spondylitis Inflammatory bowel disease spondylitis Reactive arthritis (reiter syndrome) ```
32
reactive arthritis (reiter syndrome)
Can't see, can't pee, can't climb a tree conjuncitivitis (or uveitis) urtethritis (dysuria) arthritis
33
layers of the epidermis
Come'on Lets Get Sun Burnt C - stratum Corneum (keratinocytes) L - stratum Lucidum G - stratum Granulosum S - stratum Spinosum (spines = desmosomes) B - stratum Basale (stem cells + melanocytes here)
34
5 P's of lichen Planus
``` autoimmune skin disorder Pruritic Purple Polygonal Papules Plaques ```
35
pathway of sperm during ejaculation
``` SEVEN UP Seminiferous tubules Epididymis Vas deferens (cut with vasectomy) Ejaculatory ducts (ends in prostatic urethra) N -blank Urethra (prostatic) Penis ```
36
mesonephric (wolffian) ducts develops into
``` male internal structures IN PRESENCE OF TESTOSTERONE: SEED (no prostate): Seminal vesicles Epididymis Ejaculatory ducts Ductus deferens ```
37
types of epithelial ovarian tumors
``` Serious Epithelial Malignancies are Clearly Bad Serous (most common type) Endometroid Mucinous Clear cell Brenner tumor ```
38
22q11 microdeletion presentation
CATCH-22 Cleft palate Abnormal facies Thymic aplasia → T cell deficiency → lung + viral infections Cardiac defects Hypocalcemia secondary to parathyroid hypoplasia → tetany
39
X-linked recessive disorders
``` Oblivious Female Will Give Her Boys Her x-Linked Disorders Ocular albinism Fabry disease Wiskott Aldrich syndrome G6PD deficiency Hunter syndrome Bruton agammaglobulinemia Hemophilia A + B Lesch Nyhan syndrome Duchenne + becker MD ```
40
encapsulated bacteria
``` Even Some Pretty Nasty Killers Have Shiny Bodies Escherichia coli (some strains) **Streptococcus pneumoniae Pseudomonas aeruginosa **Neisseria meningitidis Klebsiella pneumoniae **Haemophilus influenza type B Salmonella typhi group B streptococcus ```
41
HACEK organisms can cause endocarditis (G-)
``` Haemophilus aphrophilus actinobacillus Actinomycetemcomitans Cardiobacterium hominis Eikenella corrodens Kingella kingae ```
42
maculopapular rash on palms and soles
you drive Kawasaki CARS with your hands and feet: Kawasaki disease Coxsackie A Virus (hand, foot, mouth disease) Rocky Mountain Spotted 2° syphilis and Meningococcus
43
false positive VDRL or RPR (screening test that detects antibodies against cardiolipin)
``` VDRL Virus (EBV) Drugs (IVDU) Rheumatic fever Lupus (all autoimmune diseases), Leprosy Pregnancy ```
44
live attenuated vaccines
``` ATTENTion! Please Vaccinate Young Infants with MMR Regularly Polio vaccine (oral, Sabin) Varicella Yellow fever Intranasal influenza (infants) MMR Rotavirus ```
45
differential diagnosis for eosinophilia
CANADA-P Collagen vascular disease (polyarteritis nadosa, dermatomyositis) Atopic disease (allergy, asthma, Churg-Strauss - assoc. with asthma, allergic bronchopulmonary aspergillosis) Neoplasm Adrenal insufficiency (Addison disease) Drugs (NSAIDs, penicillins, cephalosporins) Acute interstitial nephritis (aka drug-induced nephritis, allergic interstial nephritis) Parasites (strongyloides, ascaris → Loeffler eosinophilic pneumonitis) other causes: HIV, hyper IgE syndrome, coccidoidomycosis
46
function of IL-1 through IL-5
HOT T-BONE stEAK IL-1: fever (HOT) IL-2: stimulates T cells IL-3: stimulates BONE marrow IL-4: stimulates Ig(E) and IgG production IL-5: stimulates Ig(A) and production and stimulate eosinophils IL-6: stimulates aKute phase protein production
47
retroperitoneal structures (behind abdomen)
``` A DUCK PEAR Adrenal glands Duodenum (2nd + 4th only) Ureters Colon (descending + ascending only) Kidneys Pancreas (not tail) Esophagus (below diaphragm - lower 2/3) Aorta and IVC Rectum ```
48
carcinoid syndrome: occur if carcinoid tumor outside of GI tract
``` BFDR Bronchospasm Flushing Diarrhea Right sided murmur (deposits in R sided valves) + edema, ascites (all = Right sided heart disease) ```
49
4 drug treatment of TB
``` RIPE Rifampin Iisoniazid Pyrazinamide Ethambutol ```
50
causes of acute pancreatitis
PANCREATITIS hyperParathyroidism causes ↑Ca Alcohol (most common**) Neoplasm: pancreatic tumor obstructs ducts → enzymes eat itself Cholelithiasis (galls stones - most common**) Rx (drugs): NRTIs for HIV, protease inhibitor for HIV: ritonavir, sulfa drugs ERCP: inject contrast into pancreatic duct (retrograde flow) Abdominal surgery hyperTriglyceridemia Infection (mumps) Trauma Idiopathic Scorpion sting
51
C's of Huntington Disease
``` CAG repeats on chrom 4 40 yo cognitive decline chorea caudate atrophy ```
52
treatment of pulmonary edema
NO LIP | Nitrates
53
drugs to avoid if have sulfa allergy
``` Sulfa Pills Frequently Cause Terrible Acute Symptoms: Sulfasalzine Sulfonamides: TMP-SMX Probenecid Furosemide (loop diuretic) Celecoxib (COX-2 inhibitor) Thiazide diuretic/TMP-SMX Acetazolamide (diuretic) Sulfonylureas ```
54
antibiotics/antiviral/antifungals to avoid in pregnancy
SAFe Children Take Really Good Care Sulfonamides: kernicterus close to delivery Aminoglycosides: ototoxicity Fluoroquinolones: articular cartilage damage Clarithromycin: embryotoxic Tetracycline: discolored teeth, inhibit bone growth Ribavirin (antiviral): teratogenic Griseofluvin (antifungal): teratogenic Chloramphenicol: gray baby syndrome *Metronidazole: mutagenesis in first tri only
55
most common causes of DIC
``` STOP Making Thrombi Sepsis (usually G-) Trauma Obstetric (amniotic fluid emboli, postpartum hemorrhage) Pancreatitis Malignancy Transfusion ```