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Flashcards in oncogenes Deck (9)
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1

K-RAS mutation

colon cancer (Kolon)
lung cancer
pancreatic cancer (panKreatic)

2

H-RAS mutation

bladder + kidney tumors (Hematuria)

3

N-RAS mutation

melanoma
hematologic malignancy
follicular thyroid cancer

4

BCR-ABL:
ABL codes for non-receptor tyrosine kinase
ABL gene translocated from 9 to BCR gene on 22 t(9;22) = philadelphia chromosome
always ON

CML

5

RET:
receptor tyrosine kinase always activated (don't need GF to bind to R outside cell anymore)

1) MEN 2A and 2B:
pheochromocytoma
medullary thyroid cancer
2) papillary carcinoma of thyroid

normal RET protein is expressed in neuroendocrine cells: adrenal medulla, parafollicular C cells of thyroid

6

HER2/neuL receptor tyrosine kinase

breast cancer
ovarian cancer
gastric cancer

7

C-myc

burkitt lymphoma

8

L-myc

lung tumors

9

M-myc

neuroblastoma: mostly in adrenal medulla

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