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Flashcards in genes of embryogenesis Deck (8)
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1

homeobox (HOX) genes

Proteins that function as transcription factors that regulate other genes
SKELETAL morphology layout in craniocaudal direction
put limbs at correct spot on body (not on head, etc)

2

HOXD-13 mutation causes

synpolydactyl: extra digits + fused

3

what drug alters HOX expression?

retinoic acid (vitamin A derivative)

4

Sonic Hedgehog gene

expressed at base of limbs in zone of polarizing activity (ZPA)
organization along craniocaudal direction (A-P)

5

SHH gene mutation causes

holoprosencephaly (etoh does too)

6

Wnt-7 gene

organization along dorsal-ventral axis (feet + nose in same direction)

7

FGF (fibroblast growth factor) gene

lengthens limbs

8

FGF R3 mutation causes

achondroplasia (short limbs)

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