coagulopathies + hypercoaguable states Flashcards Preview

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Flashcards in coagulopathies + hypercoaguable states Deck (13):
1

↑PTT
normal PT/INR

hemophilia A or B (8 or 9)

2

signs/symptoms of coagulation disorders: ↑ bleeding

microhemorrhages: nose bleed, gum bleed + macrohemorrhages: hemarthrosis, easy bruising
(vs platelet disorders only microhemorrhages)

3

↑PT
↑PTT

vitamin K deficiency

4

vitamin K

cofactor for synthesis of clotting factors:
2, 7, 9, 10 + protein C and protein S

5

causes of vitamin K deficiency

inadequate vitamin K intake
newborn: sterile flora, give vit. K injection at birth (major source is intestinal flora)
warfarin: vitamin K antagonist
end-stage liver disease: can't make CF (clinically looks like vitamin K deficiency)

6

coagulopathies: ↑ bleeding

hemophilia A
hemophilia B
vitamin K deficiency

7

hypercoagulable states

Factor V Leiden
prothrombin gene mutation
antithrombin deficiency
protein C or S deficiency

8

signs/symptoms of hypercoaguable state:

DVT
cerebral vein thrombosis
spontaneous PE (with no preceding DVT)
arterial thrombosis (less common vs vein)

9

mutant Factor 5a is resistant to inactivation by protein C → ↑coagulation

Factor V Leiden

10

mutation of guanine to adenine at 20210 position on prothrombin gene (CF 2) → ↑ prothrombin production → ↑ coagulation

prothrombin gene mutation

11

unable to inactivate thrombin (2a)→↑ coagulation
may be resistant to heparin: accelerates activity of antithrombin (may need to give higher dose)

antithrombin deficiency

12

unable to inactivate CF 5 + 8 →↑ coagulation

protein C deficiency

13

if hx of recurrent DVT or DVT with no known cause, consider

hypercoaguable state

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