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Flashcards in Hematologic Deck (59)
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31

older adults; nonspecific early symptoms; thrombus formation; hypertension, splenomegaly; ruddy complexion; erythromelalgia; excess hemorrhage (gingival, epistaxis, ecchymosis)

polycythemia vera

32

heterogeneous group of malignancies of hematopoietic stem cell derivation; probably due to genetic and environmental factors (pesticides, benzene, ionizing radiation, viruses); Philadelphia chromosome

leukemia

33

Most common from of leukemia, elderly adults

CLL

34

Form of leukemia associated with children

ALL

35

symptoms related to reduction of normal red and white blood cells (infections, bleeding, fatigue, oral ulceration); hepatosplenomegaly; lymphadenopathy

leukemia

36

Occasional infiltration of oral soft tissue with _ cells; granulocytic sarcoma/chloroma

leukemic

37

poorly understood malignancy; lesional cell (Reed-Sternberg cell) makes up only 1-3% of cells

Hodgkin's Lymphoma

38

M>F; almost uniformly begins in lymph nodes, especially the cervical and supraclavicular; fever, night sweats, pruritis

Hodgkin's Lymphoma

39

Hodgkins lymphoma histo: Reed Sternberg cells (look like kernels of popcorn

nodular lymphocyte predominant

40

Hodgkins lymphoma histo: large nuclei form; 5 subtypes

Classical Hodgkins lymphoma

41

heterogeneous group of lymphoreticular malignancies; usually arise in lymph nodes; grow as solid masses; more common in the immunocompromised

non-hodgkins

42

primarily adults; nodal and extranodal (oral); slowly growing mass; oral lesions; extranodal, "boggy" swelling, usually normal or purplish in color; may occur in bone

non hodgkins lymphoma

43

Lymphoma: _-grade lesions tend to be characterized by a follicular arrangement

low

44

Lymphoma: _-grade lesions will be more diffuse

higher

45

high-grade, undifferentiated lymphoma of B-lymphocyte origin; American (sporadic) and African (endemic) variants; thought to be associated with Epstein-Barr virus (African)

Burkitt's lymphoma

46

_ variant of Burkitts: children; more likely to affect the jaws (50-79%), especially the maxilla; swelling, tooth mobility or premature exfoliation; pain and paresthesia typically minimal

African

47

_ variant of Burkitt's: wider age range; typically presents as an abdominal mass; radiographic: early loss of lamina dura; patchy, ill-defined radiolucency

American

48

small, non-cleaved cells with scattered macrophages; "starry sky" classic pattern

burkitt's lymphoma

49

uncommon malignancy of plasma cell origin; monoclonal proliferation results in production of abnormal, nonfunctional immunoglobulin (monoclonal gammopathy, M-protein)

Multiple myeloma

50

older men; blacks>whites; bone pain, pathologic fracture; petechiae; fever; radiographic: multiple punched out radiolucencies

multiple myeloma

51

Bence Jones protein: excess light chain proteins presents in serum and urine; amyloid: deposition of Bence Jones protein

multiple myeloma

52

monoclonal sheets of malignant plasma cells; amyloid: congo red positive stain

multiple myeloma

53

solitary, monoclonal lesion of plasma cells; may progress to multiple myeloma; adult males; 55 years; most occur in bone (extramedullary if outside bone); well-defined, solitary radiolucency

plasmacytoma

54

aggressive, destructive process of T lymphocytes; diagnosis is usually made after tertiary syphilis and Wegener's granulomatosa have been ruled out

Extranodal NK/T-Cell Lymphoma Nasal Type

55

adults; nasal stuffiness, epistaxis; deep necrotic ulcerations; may progress to palatal perforation; angiocentric arrangement of atypical inflammatory cells; necrosis

Extranodal NK/T-cell lymphoma

56

neoplastic proliferation of Langerhans cells (dendritic mononuclear cells normally found in the epidermis, mucosa, lymph node, and bone marrow)

Langerhans Cell Histocytosis

57

Form of Langerhans cell histiocytosis: acute, disseminated

letterer-siwe disease

58

form of langerhans cell: chronic, disseminated

hand-schuller-christian disease

59

M=F; less than 15 years old; solitary or multiple bone lesions; "floating in air" radiograph; dull pain and tenderness often accompany bone lesions; ulcerative or proliferative gingival masses may also be seen; birbeck granules

Langerhans cell histiocytosis