Immuno receptor and cell type roles Flashcards Preview

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Flashcards in Immuno receptor and cell type roles Deck (11)
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1
Q

CD3 role

A

on T cells

T cell differentiation and activation

2
Q

T cell receptors

A

TCR

interacts with MHC II

3
Q

MHC class I

A

present endogenous Ags to Tc cells (viruses)
on all nucleated cells
recognized by CD8

4
Q

MHC class II

A

present exogenous Ags to Th cells (bacteria/etc)
in all Ag presenting cells (APCs)
recognized by CD4

5
Q

Cell type with CD4

A

T helper cells

6
Q

Cell type with CD8

A

Cytotoxic T cells (CTLs)

7
Q

Th0 cells

A

can differentiate into Th1 or Th2

8
Q

Th1 cells

A

cell mediated immunity
CD8 (CTL’s) delayed hypersensitivity
downregulates Th2 cells

9
Q

Th2 cells

A

humoral immunity
stimulate Ab production
class switching
downregulates Th1 cells

10
Q

Treg cells

A

limits activation of T cells

11
Q

Th17 cells

A

clearance of pathogens not handled by Th1 or Th2 cells

potent inflammatory/autoimmunity