Immunology Mediator roles Flashcards Preview

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Flashcards in Immunology Mediator roles Deck (16)
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1
Q

IL-1 role

A

proinflammatory
acute phase protein induction/fever
stimulates Th cells/hepatocytes/hypothalamus

2
Q

IL-2 role

A

proliferation/enhanced killing of cytotoxic T cells

secreted by Th1 cells

3
Q

IL-3 role

A

growth factor of hematopoietic cells

secreted by Th cells

4
Q

IL-4 role

A
class switching to IgE and IgG
secreted by Th2 cells onto B cells
5
Q

IL-5 role

A
class switching to IgA
secreted by Th2 cells onto B cells
6
Q

IL-6 role

A

proinflammatory
acute phase protein induction/fever
plasma cell differentiation and Ab production
secreted by macrophages and Th2 cells

7
Q

IL-7 role

A

differentiation
secreted by bone marrow/thymus
impacts B and T cell precursors

8
Q

IL-8 role

A

chemotaxis of neutrophils

secreted by macrophages

9
Q

IL-10 role

A

decrease inflammation

secreted by macrophages

10
Q

IL-12 role

A

differentiation from Th cells to Th1 cells

secreted by macrophages

11
Q

Role of IFN-alpha and IFN-beta

A

inhibit viral replication

secreted by leukocytes and fibroblasts

12
Q

Role of IFN-gamma

A

activation of macrophages

secreted by Th1 cells

13
Q

Role of TNF-alpha

A

induces cytokine secretion (proinflammatory)/cachexia

secreted by macrophages

14
Q

What can IFN-gamma tx?

A

chronic granulomatous disease

15
Q

What can IFN-beta tx?

A

multiple sclerosis

16
Q

What can IFN-alpha tx?

A

HBV/HVC/HHV-8