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Flashcards in Adult - Endocrine (sans DM) Deck (27):
1

Which is more common - hyper or hypo thyroidism?

HYPO thyroidism is more common

2

What is the most common presentation of hyperthyroidism?

Grave's disease

 

3

What is the most common presentation of HYPOthyroidism?

Hashimoto's disease

4

What are the symptoms of HYPERthyroidism?

nervousness

anxiety

fine tremor

exophthalmos

5

What are the symptoms of HYPOthyroidism?

fatigue

cramps

cold intolerance

weight gain

puffy eyes 

6

What are the labs of hyperthyroidism?

 

low TSH

high T3

7

What are the labs of hypothyroidism?

high TSH

low or low normal T4

8

How is hyperthyroid managed? (5)

  • propranalol for symptoms
  • thiourea drugs
    • methimazole (Tapazole)
    • PTU
  • radioactive iodine 131-I
  • thyroid surgery (must be euthyroid)
  • Lugol's solution

9

How is hypothyroid managed?

levothyroxine (Synthroid) 

50 - 100 mcg

10

Who typically presents with hyperthyroidism?

women between the ages of 20 and 40

11

With what condition is myxedema associated?

decompensated hypothyroidism

 

primary symptoms?

altered mental status

hypothermia

12

What condition is caused by prolonged exposure to cortisol?

Cushing's sydrome

13

What are the potential causes for Cushing's syndrome?

  • prolonged use of corticosteroids 
  • hypersecretion of ACTH by the pituitary
  • adrenal tumor

14

Signs and symptoms of Cushing's syndrome

what does cortisol due to fat distribution in the body?

Due to too much steroid causes fat redistribution:

  • moon face
  • buffalo hump
  • central obesity

15

Signs and symptoms of Cushing's syndrome - 

what effect does increased ACTH have?

Increased androgens which cause: 

  • acne
  • purple striae
  • hirsutism

16

Signs and symptoms of Cushing's syndrome - 

what effect do steroids have on the cells with regard to glucose? (6)

 

"THINK DM"

Steroids prevent the cells from taking up glucose, causing:

  • hyperglycemia
  • weakness
  • polyuria
  • polydipsia
  • labile mood
  • frequent infection

17

Signs and symptoms of Cushing's disease - 

what effect does cortisol have on the vasculature? (1)

Vasoconstriction leading to HTN

18

Signs and symptoms of Cushing's syndrome

what is the cause of poor healing?

steroids decrease inflammation 

increase blood glucose

19

What are the significant labs of Cushing's syndrome

HYPERglycemia

HYPERnatremia

HYPOkalemia

20

What tests can be used to differentiate between causes of Cushing's syndrome?

  • ACTH
  • dexamethasone suppresion test

21

What is the management of Cushing's Syndrome?

depends on the cause

  • d/c medication if causative
  • resection of pituitary adenoma
  • surgical removal of adrenal tumor

22

Primary adrenal cortical insufficiency.

Addison's disease

23

What deficiencies characterize Addison's disease?

cortisol

androgens 

aldosterone

24

What do androgens and aldosterone combine to form?

mineralocorticoids

25

What are the signs and symptoms of Addison's disease?

  • hyperpigmentation in buccal mucosa and skin creases
  • scant axillary and pubic hair
  • orthostasis and hypotension

26

What are the significant labs in Addison's disease?

HYPOglycemia

HYPOnatremia

HYPERkalemia

27

What is the treatment in Addison's disease?

replacement of: 

glucocorticoids (ex: hydrocortisone)

AND 

mineralocorticoids (ex: fludrocortisone/Florinef)