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Flashcards in Hematologic System Deck (43):
1

Anemia
definition

Decrease in number or function of RBCs

1

RBC function

Carry oxygen

2

Polycythemia
definition

Increase in number of RBCs

3

Site of formation of new blood elements in an adult

Bone marrow

4

Hematopoiesis
def

Formation of new blood elements

5

Site of hematopoiesis in the fetal period

Spleen
Liver
Lymph nodes

6

Role of spleen in adult

Filter out

infectious organisms
malformed, damaged, or old RBCs

8

How is RBC production stimulated?

kidneys secrete erythropoietin (EPO) stimulating the bone marrow to produce RBCs

8

Hematocrit
def, normal range

Percent of the blood that is RBCs

40-50% men
35-45% women

9

S/sx of anemia

TACHYCARDIA - effort to increase perfusion to the tissues
PALLOR - blood be shunted to brain, central organs
DOE - as a result of heart and lungs struggling to keep up with demand

10

Hemoglobin
def, normal range

Molecule of RBC that carries O2

14-18 g/dl men
12-16 g/dl women

11

RBCs are also known as

Erythrocytes

12

Serum Iron
normal range

50-150 mcg/dL

13

TIBC
stands for, normal range

Total Iron Binding Capacity

250-450 mcg/dL

15

MCV
def, normal range

Mean Corpuscular Volume

average volume and size of RBC

80-100 fl

16

MCHC
def, normal range

Mean Corpuscular Hgb Concentration

average hemoglobin concentration in RBC; "color"

32-36%

17

Low MCV
range, AKA

< 80 fl

aka MICROCYTIC

18

Normal MCV
range, AKA

80-100 fl

aka NORMOCYTIC

18

Low MCHC
range, AKA

< 32%

aka HYPOCHROMIC

19

High MCV
range, AKA

> 100 fl

aka MACROCYTIC

20

Normal MCHC
range, AKA

32-36%

aka NORMOCHROMIC

21

High MCHC
range, AKA

theoretically > 36%

but most texts agree there's no such thing as HYPERCHROMIC

22

Anemia pairs:

MICRO-cytic

HYPO-chromic

Iron deficiency anemia

Thalassemia

23

Iron deficiency anemia
___ -cytic, ___ -chromic

MICRO-cytic

HYPO-chromic

24

Thalassemia
___ -cytic, ___ -chromic

MICRO-cytic

HYPO-chromic

25

Anemia pairs:

MACRO-cytic

NORMO-chromic

Folic acid deficiency

Pernicious anemia

26

Folic acid deficiency
___ -cytic, ___ -chromic

MACRO-cytic

NORMO-chromic

27

Pernicious anemia
___ -cytic, ___ -chromic

MACRO-cytic

NORMO-chromic

28

Anemia pairs:

NORMO-cytic

NORMO-chromic

Anemia of chronic disease

Sickle cell anemia

29

Anemia of chronic disease
___ -cytic, ___ -chromic

NORMO-cytic

NORMO-chromic

30

Sickle cell anemia
___ -cytic, ___ -chromic

NORMO-cytic

NORMO-chromic

31

Which anemias are characterized by a BIG BEEFY TONGUE?

(aka GLOSSITIS)

Folic acid deficiency

Pernicious anemia

32

What's the only anemia characterized by neurological symptoms?

Pernicious anemia

33

What is the only anemia described as hemolytic?

Sickle cell anemia

34

What is the long name for vitamin B12?

Cyanocobalamin

35

What does serum ferritin represent?

The stores of iron in the CLOSET

36

RDW in iron deficiency anemia

increased

37

RCDW/RDW

Red Cell Distribution Width
red cell size variation

11.5 - 14.5 %
provides clues to differentiate between different anemias

38

RDW in thalassemia

slightly increased or normal

39

RDW in anemia of chronic disease

normal

40

What is a reticulocyte?

baby RBC

41

What is the normal range of reticulocytes in circulation?

1 - 2 %

42

What does reticulocyte count tell you?

provides information about the health of bone marrow and response to anemia