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Flashcards in Gero Pharm Deck (18):
1

Of pharmacokinetics and pharmacodynamics, which differs among individuals?

pharmacokinetics differs among individuals

pharmacodynamics remain constant for all people

2

What is pharmacokinetics?

how the body interacts with drugs

includes - ADME
absorption
distribution
metabolism
elimination

3

Of the 4 pharmacokinetic actions which are affected by the aging process and which are not?

absorption and distribution are NOT affected

metabolism may be reduced - liver impairment

elimination is significantly reduced due to decline in renal function

4

Motto for prescribing to the elderly?

"start low and go slow"

5

What are pharmacodynamics?

how the drug interacts with the body

this is the same for every human

6

pharmacogenetics vs. pharmacogenomics

p-genetics begins with unexpected drug response, looks for genetic cause

p-genomics begins with looking at the genome

7

What are the four categories of adverse reactions in the elderly?

Effects on:
o CNS
o anticholinergic
o movement / balance
o bone / supporting structures

8

Examples of CNS adverse reactions (5)

sedation
memory loss
dizziness
depression
confusion

9

Drugs likely to cause CNS adverse effects (6)

Benzos
BBs
steroids
cimetidine ---> "disaster drug" (Tagamet)
narcotics
diuretics

10

Examples of anticholinergic effects (4)

can't see
can't pee
can't spit
can't shit

11

Drug classes likely to cause anticholinergic effects (4)

cholinergic agonists (antagonist?)
decongestants
tricyclics
antipsychotics

12

Drugs likely to have adverse effects on balance and movement (6)

ASA
furosemide
BBs
vasodilators
aminoglycosides
phenytoin

13

Drugs likely to have adverse effects on bone and supporting structures (3)

heparin
steroids
lithium

14

OTC bad boys

cimetidine

inhibits CYP 450

many, many drug interactions

15

OTC bad boys

decongestants

decreases antihypertensives

anticholinergic

16

OTC bad boys

NSAIDs

decrease renal blood flow

reducing drug elimination

17

OTC bad boys

niacin

increase antihypertensives

18

In a healthy adult, what is the effect of aging on renal function?

~40% reduction by the elder years :-(