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Flashcards in Antipsychotics Deck (11):
1

What are the typical low potency antipsychotics?

chlorpromazine
thioridazine

2

What are the typical high potency antipsychotics?

haloperidol
fluphenazine
loxapine
thiothixene
trifluoperazine

3

What are the atypical antipsychotics?

It is atypical for old closets to quietly whisper A->Z
olanzapine
clozapine
quetiapine-good to use to treat psychosis from Parkinson's treatment
risperidone
aripiprazole
ziprasidone

4

SE of low potency typical antipsychotics?

anticholinergic mainly, also hypotension and sedation
inhibit D2, muscularinic, alpha1, histamine

5

SE of high potency typical antipsychotics?

less anticholinergic, more EPS and tardive dyskinesia
also, neuroleptic malignant syndrome

6

SE of atypical antipsychotics?

fewer anticholinergic and EPS
but get weight gain
olanzapine--weight gain and diabetes
risperidone--increased prolactin
ziprasidone--extra QT elongation (they all do tho)
clozapine-agranulocytosis

7

Receptors inhibited by atypical antipsychotics?

D2, 5-HT, alpha, histamine

8

What is the progression of SE of antipsychotics?

First several days--acute dystonia (treat with benztropine or anti-cholinergic)
can also see torticollis (twisting neck)
First month: parkinsonism (bradykinesia
First 2 months: akathisia (restlessness)
Months-years: tardive dyskinesia (mouth thing) Often irreversible.

9

What are the features of neuroleptic malignant syndrome?

delirium, or altered mental status (encephalopathy)
autonomic instability (tachycardia)
muscle rigidity-->myoglobinuria, hyperpyrexia

10

Which drugs help treat neuroleptic malignant syndrome?

Dantrolene
Bromocriptine (dopamine agonist-used in hyperprolactinemia)

11

What is the MOA of dantrolene and what else is it used to treat?

inhibits release of Ca++ from SR
also used to treat malignant hyperthermia from inhaled anesthetics