Flashcards in Antipsychotics Deck (11):
What are the typical low potency antipsychotics?
What are the typical high potency antipsychotics?
What are the atypical antipsychotics?
It is atypical for old closets to quietly whisper A->Z
quetiapine-good to use to treat psychosis from Parkinson's treatment
SE of low potency typical antipsychotics?
anticholinergic mainly, also hypotension and sedation
inhibit D2, muscularinic, alpha1, histamine
SE of high potency typical antipsychotics?
less anticholinergic, more EPS and tardive dyskinesia
also, neuroleptic malignant syndrome
SE of atypical antipsychotics?
fewer anticholinergic and EPS
but get weight gain
olanzapine--weight gain and diabetes
ziprasidone--extra QT elongation (they all do tho)
Receptors inhibited by atypical antipsychotics?
D2, 5-HT, alpha, histamine
What is the progression of SE of antipsychotics?
First several days--acute dystonia (treat with benztropine or anti-cholinergic)
can also see torticollis (twisting neck)
First month: parkinsonism (bradykinesia
First 2 months: akathisia (restlessness)
Months-years: tardive dyskinesia (mouth thing) Often irreversible.
What are the features of neuroleptic malignant syndrome?
delirium, or altered mental status (encephalopathy)
autonomic instability (tachycardia)
muscle rigidity-->myoglobinuria, hyperpyrexia
Which drugs help treat neuroleptic malignant syndrome?
Bromocriptine (dopamine agonist-used in hyperprolactinemia)