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Flashcards in Obesity Deck (10):
1

What do adipocytes do?

Store fat, triglycerides
synthesize fatty acids from carbs
break down stored fats for energy
produce leptin

2

What are the functions of leptin?

inhibit lateral hypothalamus to decrease hunger b/c it is naturally hungry
stimulates the ventromedial nucleus of the hypothalamus b/c it is naturally skinny

3

What happens when you exercise or are stressed?

mobilize fat for energy!
increase in sympathetic stimulation increases NE & Epi
Increase in ACTH and therefore, Cortisol

increase in lipase in fat cells

4

What is lipodystrophy?

atrophy or hyperplasia of fat cells so that you get distributions of fat
Ex: buffalo hump in cushing's

5

What are some causes of lipodystrophy?

leptin deficiency
HIV meds, like protease inhibitors

6

what are some meds that can cause obesity?

atypical antipsychotics
mirtazapine
insulin, TZD, sulfonylureas
some progestins

7

What is the diagnostic criteria for metabolic syndrome?

3/5
1. abdominal obesity: men>40, women>35"
2. high triglycerides: >150
3. Low HDL, Men130/85
5. fasting glucose>100

8

Describe the progression of the liver problems caused by obesity.

Fatty Liver-->NASH-->Cirrhosis-->Hepatocellular Carcinoma

9

Which signs would you see that would point to non-alcoholic steatohepatitis?

histo: fatty liver + inflammation w/ neutrophils and fibrosis
Labs: elevated ALT and AST, ALT>AST, elevated Alk phosph

10

What are the imaging methods for diagnosis of NASH?

LIVER US, CT, MRI
magnetic resonance spectroscopy (gold standard)
liver biopsy