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Flashcards in Lymphoma Deck (18):
1

What differentiates Hodgkin from non-Hodgkin lymphoma?

Hodgkin: single group of lymph nodes, not extra nodal, better prognosis
Reed-sternberg cells
bimodal: young and old
definite B symptoms
associated w/ EBV

Non-Hodgkin: multiple nodal involvement, sometimes extranodal, usually B cells
variable age
few B symptoms
associated w/ HIV and autoimmune

2

What do Reed-sternberg cells look like?

owl eye
the more of these, the worse the prognosis

3

Describe the presentation of Hodgkin lymphoma?

painless nontender LAD
mediastinal LAD
B symptoms: low grade fever, night sweats, weight loss
sometimes pruritis
**wanna r/o TB

4

What are the different Hodgkin lymphoma subtypes?

Lymphocyte Predominant
Nodular Sclerosing
Mixed Cellularity
Lymphocyte-depleted

5

Describe the features of lymphocyte predominant?

L>RS
good prognosis
rare
younger males

6

Describe the features of nodular sclerosing Hogdkin lymphoma.

L>RS
good prognosis
most common subtype!
Men=Women
Biopsy: sclerosis, collagen formation, fibrosis

7

Describe the presentation of mixed cellularity hodgkin lymphoma.

RS & L
worse prognosis
2nd most common!

8

Describe the features of the lymphocyte-depleted hodgkin lymphoma.

RS>L
poor prognosis

9

Which CDs are present on Reed Sternberg cells?

2 owl eyes X 15 = 30
CD15
CD30

10

We are talking non-Hodgkin lymphoma. What are the B cell lymphomas?

Burkitt Lymphoma
Diffuse large B cell lymphoma--most common among adults and overall!
Follicular Lymphoma
Mantle Cell Lymphoma
Lymphoblastic lymphoma-most common in children!
Small lymphocytic lymphoma-lymphoma version of CLL
Marginal Cell MALToma

11

We are talking non-Hodgkin lymphoma. What are the T cell lymphomas?

Adult T cell lymphoma
Mycosis Fungoides/Sezary Syndrome
Intestinal T cell lymphoma-from long term celiac dx

12

What are the important features of Burkitt lymphoma?

young adults
t(8;14) translocation. Get more c-myc oncogene instead of heavy chain immunoglobulin
Starry sky on histo w/ lymphocytes as sky and macrophages as stars
Associated w/ EBV and jaw lesion in Africa. Sporadic form found in pelvis and abdomen

13

What are the important features of Diffuse large B cell lymphoma?

most common in adults and overall
seen in elderly
t(14;18) translocation in 30%. Get more BCL-2

14

What are the important features of follicular lymphoma?

t(14;18) get more BCL-2 instead of Ig heavy chain. Inhibits apoptosis.
waxing and waning LAD

15

What are the important features of Mantle Cell Lymphoma?

Older males
t(11;14) get more cyclin D1 and entry into S phase and less heavy chain Ig
CD5+

16

Which conditions cause marginal cell MALToma?

Sjogren syndrome
H. Pylori
Hashimoto's

17

What are the important features of Adult T cell lymphoma?

HTLV
associated w/ IV drug abuse
cutaneous lesions
lytic bone lesions-hypercalcemia

18

What are the important features of Mycosis Fungoides/Sezary?

skin patches/plaques
strange CD4+ cells w/ cerebriform nuclei
if it gets into blood-->Sezary