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Flashcards in Adrenal path Deck (18):
1

What is the primary cause of hyperaldosteronism?

Conn syndrome
get HTN, hypokalemia, metabolic alkalosis
use spironolactone, eplerenone, surgical resection to treat

2

What is the usual cause of secondary hyperaldosteronism?

Renal Artery Stenosis
decreased blood flow, renin increases b/c thinks low BP

3

What is Waterhouse Friedrichsen syndrome?

cause of 1* adrenal insufficiency
from N. meningitidis infection-->DIC
get adrenal hemorrhage

4

what is the treatment for addison's?

glucocorticoid
fludrocortisone--mineralcorticoid
**only type of adrenal insufficiency that has both low cortisol and low aldosterone

5

Which forms of adrenal insufficiency show skin pigmentation?

only primary
also the only one w/ messed up aldosterone, w/ high ACTH, w/ any hypotension issues

6

What is the usual cause of 3* adrenal insufficiency?

decreased CRH from hypothalamus
after abrupt cessation of exogenous glucocorticoids

7

What is the origin of a neuroblastoma?

neural crest cells
happens along sympathetic trunk
usually adrenal gland

seen in children! Adrenal medulla. mass can cross midline unlike Wilm's tumor

8

What is an important histo marker of neuroblastoma?

Homer-Wright Rosettes

9

What are some important lab/genetic markers of neuroblastoma?

increased HVA and MVA in urine
Bombesin and Neuron specific enolase +
N-myc oncogene

10

What is the rule of 10s/90s for pheochromocytoma?

90% benign
90% unilateral
90% adrenal medulla
90% don't calcify
90% adults

11

What are the 5Ps of pheochromocytoma?

Pressure (BP up episodically)
Pain (HA)
Perspiration (diaphoresis)
Palpitations (tachycardia)
Pallor

12

What is the main lab marker for pheochromocytoma?

metanephrines in urine and plasma

13

Which conditions is pheochromocytoma associated with?

NF1
MEN2A
MEN2B
Von Hippel Lindau disease

14

What is the treatment for pheochromocytoma?

alpha blockers (nonspecific, irreversible)-->phenoxybenzamine
then beta blocker
surgical resection

15

What are some EPO secreting tumorS?

Pheochromocytoma
Renal Cell Carcinoma
Hemangioblastoma
Hepatocellular Carcinoma

16

Which malignancies are associated w/ MEN1?

3Ps
parathyroid tumor
pituitary tumor
pancreatic tumor

17

What is associated w/ MEN2A?

2Ps, 1 M
parathyroid hyperplasia
pheochromocytoma
medullary thyroid carcinoma

RET gene

18

What is associated w/ MEN2B?

1P, 2 Ms
pheochromocytoma
medullary thyroid carcinoma
mucosal neuromas in oral cavity and intestine

RET gene