Flashcards in Adrenal path Deck (18):
What is the primary cause of hyperaldosteronism?
get HTN, hypokalemia, metabolic alkalosis
use spironolactone, eplerenone, surgical resection to treat
What is the usual cause of secondary hyperaldosteronism?
Renal Artery Stenosis
decreased blood flow, renin increases b/c thinks low BP
What is Waterhouse Friedrichsen syndrome?
cause of 1* adrenal insufficiency
from N. meningitidis infection-->DIC
get adrenal hemorrhage
what is the treatment for addison's?
**only type of adrenal insufficiency that has both low cortisol and low aldosterone
Which forms of adrenal insufficiency show skin pigmentation?
also the only one w/ messed up aldosterone, w/ high ACTH, w/ any hypotension issues
What is the usual cause of 3* adrenal insufficiency?
decreased CRH from hypothalamus
after abrupt cessation of exogenous glucocorticoids
What is the origin of a neuroblastoma?
neural crest cells
happens along sympathetic trunk
usually adrenal gland
seen in children! Adrenal medulla. mass can cross midline unlike Wilm's tumor
What is an important histo marker of neuroblastoma?
What are some important lab/genetic markers of neuroblastoma?
increased HVA and MVA in urine
Bombesin and Neuron specific enolase +
What is the rule of 10s/90s for pheochromocytoma?
90% adrenal medulla
90% don't calcify
What are the 5Ps of pheochromocytoma?
Pressure (BP up episodically)
What is the main lab marker for pheochromocytoma?
metanephrines in urine and plasma
Which conditions is pheochromocytoma associated with?
Von Hippel Lindau disease
What is the treatment for pheochromocytoma?
alpha blockers (nonspecific, irreversible)-->phenoxybenzamine
then beta blocker
What are some EPO secreting tumorS?
Renal Cell Carcinoma
Which malignancies are associated w/ MEN1?
What is associated w/ MEN2A?
2Ps, 1 M
medullary thyroid carcinoma