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Flashcards in RNA viruses Deck (39):
1

What are the reoviruses and their structures?

dsRNA, non-enveloped
icosahedral
Coltivirus
Rotavirus

2

What is Coltivirus?

Colorado Tick Fever
acute flu illness

3

What is rotavirus?

#1 cause of fatal diarrhea in children
increases in winter months in day care centers
infantile gastroenteritis

4

What are the picornaviruses and their structure?

non-enveloped
ssRNA linear
PERCH
poliovirus
echovirus
rhinovirus
coxsackievirus
HAV

5

What happens w/ polio?

damage to the anterior motor horns
motor neurons are damaged in the pons and medulla
paralysis

6

What's the deal with echovirus?

picornavirus
aseptic meningitis
myocarditis
URI
**get outbreaks in the summer months

7

What are the 2 causes of the common cold?

rhinovirus--picornavirus
coronavirus

8

What's the deal with the coxsackie virus?

hand foot and mouth disease
aseptic meningitis
myocarditis
pericarditis
herpangina

9

Which of the picornaviruses are enteroviruses?

poliovirus
echovirus
coxsackievirus

10

What is the structure/function of the hepevirus?

non-enveloped
ssRNA, linear
HEV

11

What's the deal with the caliciviruses?

non-enveloped
SSRNA, linear
norovirus--viral gastroenteritis
**Taking a cruise off the coast of California

12

What is the structure of flaviviruses?

enveloped
SSRNA linear
HY DSW shoes
HCV
Yellow fever
Dengue
St. Louis Encephalitis
West Nile Virus

13

What's the deal with yellow fever?

flavivirus
aedes mosquitoes
monkey or human reservoir
Fever, black vomit (coffee ground emesis)
Jaundice
Hemorrhagic disease-purpura, petechiae, epistaxis
Histo: councilman bodies (eosinophilic apoptotic globules) in liver

Subsaharan Africa
South America

14

What is the deal with dengue?

mosquito-form
Break bone fever--muscle/joint pain
Retro-orbital HA
Hemorrhagic fever

Tourniquet test--see petechiae when you leave the BP cuff on

15

What are the arboviruses that can cause encephalitis?

arbovirus-arthropod vector
St. Louis encephalitis-flavivirus
Eastern Equine Encephalitis-toga virus
Western Equine Encephalitis-toga
California Encephalitis--bunyavirus

16

What is the structure of toga viruses? What are they?

enveloped
SSRNA linear
Rubella
Eastern Equine Encephalitis
Western Equine Encephaliits

17

What's the deal with rubella?

Fever
LAD
arthralgias
fine rash

Congenital Rubella Syndrome (toRch)

18

What are the features of congenital rubella syndrome?

blueberry muffin
extramedullary hematopoiesis
cardiac defects: patent ductus arteriosus, pulmonic stenosis
cataracts
deafness

19

What are the retroviruses?

enveloped
SSRNA linear, 2 copies
HTLV-T cell leukemia
HIV-AIDs

**have reverse transcriptase

20

What are the features of the orthomyxo viruses?

enveloped
SS neg. linear

Influenza virus

21

What are the 2 important components of the influenza virus?

What is the risk of the influenza virus?

Who should get it?

hemagglutinin--promotes viral entry
neuraminidase--promotes release of viral progeny

**could get super infections w/ S. aureus, S. pneumo, H. influenza pneumonias

>6 mo you should have it!

22

What is the makeup of the vaccine for flu?

Trivalent: 2A, 1 B
Quadrivalent: 2A, 2B

**can get intranasal LAV if you are>2yo and less than 50 yo and not sick or pregnant

23

What are the features of the paramyxoviruses?

enveloped
SS neg. strand linear
PaRaMyxovirus
Parainfluenza-Croup
RSV
Measles, Mumps

24

What are the features of croup?

caused by parainfluenza virus
laryngeo-tracheo-bronchitits
seal-like barking cough
inspiratory stridor
steeple sign on X-ray

**severe: pulsus paradoxus

Treatment: epi, dexamethasone, O2

25

What are the important features of RSV?

bronchiolitis and pneumonia
brassy cough, expiratory wheezing, resp distress
seen in winter months
F fusion protein fuses w/ other cells and get a giant syncytium

26

What is the treatment sometimes used for RSV?

palivizumab
but mainly supportive

27

Which conditions are caught during the winter months? Summer months?

Winter months:
RSV
ROtavirus
Influenza

Summer:
Enteroviruses, coxsackie, polio
Arboviruses

28

What is ribavirin and what does it help with?

guanosine analog drug
competitively inhibits IMP dehydrogenase
helps w/ Hep C and RSV

SE: teratogen, hemolytic anemia

29

What are the 2 drugs to treat Hep C?

ribavirin
IFNalpha

30

What are the important features of measles?

aka RUbeola
3Cs
cough
coryza-runny nose
conjunctivitis
Koplik spots
maculopapular rash head-->feet

Vit A may help

31

What are the important features of mumps?

Mumps uses POM POMS
Parotitis
Orchiitis-->infertility
Meningitis

32

What are the rhabdoviruses?

enveloped
SS neg. linear RNA
Rabies

33

What are the important features of rabies?

bullet-shaped capsid
negri bodies on histo

Fever, malaise N/V-->agitation, photophobia, hydrophobia, hallucinations, hypersalivation-->paralysis, coma, death

**travels up peripheral nerves to CNS via retrograde transport

34

What are the important features of the filoviruses?

encapsulated single stranded neg. RNA
Ebola
Marburg

35

What are the important features of Ebola virus?

targets endothelial cells, phagocytes, hepatocytes
begins with fever, myalgia
then D/V
diffuse hemorrhage, DIC, shock

*transmission via direct contact w/ bodily fluids

36

Which viruses and bacteria can you contract from animal urine?

hantavirus
lass virus
LCM virus

bacteria-leptospirosis

37

What are the important features of the hantavirus?

bunyavirus
hemorrhagic fever
pulmonary syndrome: fever, pulmonary edema, resp failure
spread by aerosolized mouse urine

38

What are the important features of H1N1?

Swine flu
flu + GI symptoms
give oseltamivir or zanamivir

39

What are the important features of H5N1?

Avian flu
severe
URI, GI, fever, pancytopenia, increased ALT/AST
treat w/ oseltamivir