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Flashcards in Minerals Deck (17):
1

Where is iron stored?

liver, spleen, bone marrow

2

Which form of iron is considered an acute phase reactant?

ferritin (storage form)
*store out of access to organisms that want it.

3

Which form of iron increases in iron deficiency anemia?

transferrin. transfers iron around body, looking for iron w/ high capacity, but low saturation

4

What are the 2 organs that mercury accumulates in?

kidney and brain

5

What are some symptoms of mercury poisoning?

abdominal pain
acrodynia: peeling of fingertips
peripheral neuropathy
tremor
excitability
insomnia

6

Where is mercury found?

Fish: shark, swordfish, tilefish, king mackerel (pregnant women avoid!!)
Old thermometers and batteries

7

Zinc is important for like everything! WHat are some especially important things?

Would Healing
Immune System
Zinc Finger Motifs-transcription
function of carbonic anhydrase and lactate dehydrogenase

8

What is a crazy rash that is seen w/ zinc deficiency?

acrodermatitis enteropathica
scaly plaques face or anus

9

Why is heme synthesis decreased w/ lead poisoning?

b/c lead inhibits ferrochelatase and ALA dehydratase

10

What is the treatment for lead poisoning?

EDTA and succimer (kids)
Severe cases: Dimercaprol

11

Give 2 histo features of lead poisoning.

Sideroblasts on peripheral smear. Causes sideroblastic anemia

basophilic stippling from aggregates of rRNA (lead inhibits rRNA degradation)

12

What can you see on X-ray for lead poisoning?

lead lines on long bones metaphyses...a part of cartilage remodeling
also see lead lines on teeth and gingivae (Burton lines)

13

Give the important symptoms of lead poisoning.

LEAD
Lead Lines
Encephalopathy and erythrocyte basophilic stippling
Abdominal Colic and Sideroblastic Anemia
Drops-wrist and foot.

14

What is the usual presentation of iron poisoning?

children who eat vitamins w/ lots of iron

15

What is the MOA for iron poisoning?

cell death due to per oxidation of membrane lipids and generation of free radicals

16

What are the initial symptoms of iron poisoning? After 72 hours? 2-8 weeks later?

Immediate:
gastric bleeding, hematemesis, abdominal pain

72 hours: metabolic acidosis

2-8 weeks: GI scarring-->obstruction

17

What is used for OD of iron?

deferoxamine and dialysis