Flashcards in Minerals Deck (17):
Where is iron stored?
liver, spleen, bone marrow
Which form of iron is considered an acute phase reactant?
ferritin (storage form)
*store out of access to organisms that want it.
Which form of iron increases in iron deficiency anemia?
transferrin. transfers iron around body, looking for iron w/ high capacity, but low saturation
What are the 2 organs that mercury accumulates in?
kidney and brain
What are some symptoms of mercury poisoning?
acrodynia: peeling of fingertips
Where is mercury found?
Fish: shark, swordfish, tilefish, king mackerel (pregnant women avoid!!)
Old thermometers and batteries
Zinc is important for like everything! WHat are some especially important things?
Zinc Finger Motifs-transcription
function of carbonic anhydrase and lactate dehydrogenase
What is a crazy rash that is seen w/ zinc deficiency?
scaly plaques face or anus
Why is heme synthesis decreased w/ lead poisoning?
b/c lead inhibits ferrochelatase and ALA dehydratase
What is the treatment for lead poisoning?
EDTA and succimer (kids)
Severe cases: Dimercaprol
Give 2 histo features of lead poisoning.
Sideroblasts on peripheral smear. Causes sideroblastic anemia
basophilic stippling from aggregates of rRNA (lead inhibits rRNA degradation)
What can you see on X-ray for lead poisoning?
lead lines on long bones metaphyses...a part of cartilage remodeling
also see lead lines on teeth and gingivae (Burton lines)
Give the important symptoms of lead poisoning.
Encephalopathy and erythrocyte basophilic stippling
Abdominal Colic and Sideroblastic Anemia
Drops-wrist and foot.
What is the usual presentation of iron poisoning?
children who eat vitamins w/ lots of iron
What is the MOA for iron poisoning?
cell death due to per oxidation of membrane lipids and generation of free radicals
What are the initial symptoms of iron poisoning? After 72 hours? 2-8 weeks later?
gastric bleeding, hematemesis, abdominal pain
72 hours: metabolic acidosis
2-8 weeks: GI scarring-->obstruction