Flashcards in Depression Deck (30):
What are the Kubler Ross stages of grief?
**can happen with loss or imminent loss or any major life event
What are the risk factors for suicide?
Feelings of hopelessness or worthlessness
increased age (younger-attempt more, older-successful more)
Male sex (women attempt more, men succeed more)
Access to weapons (firearms)
Hx of suicide attempt
Age (young & old)
EtoH or drug use
Rational thinking gone
Social support lacking
What is required for diagnosis of Major Depressive Disorder?
5/9 SIGECAPS for >2 wks, must include anhedonia or depressed mood
What is persistent depressive disorder (dysthymia)?
depression (sometimes milder)>2 years
What is atypical depression?
mood reactivity (happier when good things happen)
interpersonal rejection sensitivity
1. CBT & SSRIs
2. MAO inhibitors
What are the features of sleep in MDD?
decreased REM latency
Increased REM early in sleep cycle
less slow wave sleep
**repeated nighttime awakenings and early morning awakening
What are the SSRIs?
Flashbacks paralyze senior citizens
What are the SE of SSRIs?
risk for serotonin syndrome
SIADH, GI distress
What are the SNRIs? What is their MOA?
inhibit 5-HT and NE reuptake
What else is venlafaxine used for?
generalized anxiety disorder
What else is duloxetine used for?
diabetic peripheral neuropathy, chronic pain
What is minacipran used for?
What are the TCAs? What is their MOA?
**inhibit 5-HT and NE reuptake
What is a special function of imipramine ?
helps w/ bed wetting
What else is clomipramine used for?
OCD, like trichotillomania
What are the SE of TCAs?
anti-Cholinergic: tachycardia, urinary retention, dry mouth, confusion, hallucination
Cardiotoxicity: prolong QT interval, arrhythmias
CNS toxicity: seizures, coma
What is the treatment for OD on TCAs?
What are some MAOIS?
MAO Takes Pride In Shanghai
What else are selegiline and rasagiline used for? MOA?
specifically inhibit MAO-B which break down dopamine
used to treat Parkinson's
What is the SE of MAOIs?
HTN crisis w/ ingestion of tyramine (in old cheese etc)
What does tyramine do exactly at nerve terminals?
stimulates release of NE along with amphetamines and ephedrine
What are some drugs that when taken together could cause serotonin syndrome?
St. John's Wart
What is the MOA of bupropion?
we don't know, but increases NE and dopamine
What are the side effects of bupropion?
seizures, esp if anorexic or bulimic
NO SEXUAL SIDE EFFECTS
What is another indication for bupropion?
What is the MOA of mirtazapine?
alpha 2 antagonist
weirdly 5-HT2 and 5-HT3 antagonist
What are the side effects of mirtazapine?
sedation and dry mouth
increase in appetite and weight gain
great for skinny insomniacs who are elderly
What is the MOA for trazadone and nefazadone?
inhibits 5-HT2 and alpha 1
What is the main indication for trazadone and main SE?
used for insomnia (not really for depression)
main side effect is priapism.