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Flashcards in RBC basics Deck (10)
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1
Q
Which protein is responsible for the flexibility and biconcave shape of the RBC? Which conditions is it compromised in?
A
spectrin
sickle cell anemia
hereditary spherocytosis
2
Q
What is the average lifespan of RBCs?
A
120 days
3
Q
What is anisocytosis?
A
variation in the size of RBCs
4
Q
What is poikilocytosis?
A
variation in the shapes of RBCs
5
Q
A, B, Rh...which of these antigens have IgM antibodies against them and which have IgG antibodies?
A
A, B-->IgM antibodies
Rh-->IgG antibodies. The only one that causes problems for baby, b/c only IgG crosses the placenta
6
Q
What type of reaction is it when there is transfusion that is incompatible?
A
Type II hypersensitivity (antibody-mediated)
7
Q
When do you see erythroblastosis fetalis?
A
mom is exposed to Rh+ when she is Rh- during first pregnancy during delivery
second pregnancy, she has anti-Rh-IgG antibodies. these cross the placenta and attack the blood of the fetus
8
Q
What are the features of erythroblastosis fetalis?
A
anemia b/c of hemolysis of RBCs from mom's Ab
jaundice--sometimes kernicterus
hydrops fetalis (generalized fetal edema)
intrauterine death
9
Q
When should anti-RhD-immunoglobulin or RhoGAM be given to mom?
A
28 weeks (3rd tri) of 1st pregnancy
traumatic event
w/i 3 days of delivery
10
Q
Which conditions can cause target cells?
A
HALT said the hunter to the target
HbC disease
Asplenia
Liver dx
Thalassemia