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Flashcards in RBC basics Deck (10):
1

Which protein is responsible for the flexibility and biconcave shape of the RBC? Which conditions is it compromised in?

spectrin
sickle cell anemia
hereditary spherocytosis

2

What is the average lifespan of RBCs?

120 days

3

What is anisocytosis?

variation in the size of RBCs

4

What is poikilocytosis?

variation in the shapes of RBCs

5

A, B, Rh...which of these antigens have IgM antibodies against them and which have IgG antibodies?

A, B-->IgM antibodies
Rh-->IgG antibodies. The only one that causes problems for baby, b/c only IgG crosses the placenta

6

What type of reaction is it when there is transfusion that is incompatible?

Type II hypersensitivity (antibody-mediated)

7

When do you see erythroblastosis fetalis?

mom is exposed to Rh+ when she is Rh- during first pregnancy during delivery
second pregnancy, she has anti-Rh-IgG antibodies. these cross the placenta and attack the blood of the fetus

8

What are the features of erythroblastosis fetalis?

anemia b/c of hemolysis of RBCs from mom's Ab
jaundice--sometimes kernicterus
hydrops fetalis (generalized fetal edema)
intrauterine death

9

When should anti-RhD-immunoglobulin or RhoGAM be given to mom?

28 weeks (3rd tri) of 1st pregnancy
traumatic event
w/i 3 days of delivery

10

Which conditions can cause target cells?

HALT said the hunter to the target
HbC disease
Asplenia
Liver dx
Thalassemia