Flashcards in RBC basics Deck (10):
Which protein is responsible for the flexibility and biconcave shape of the RBC? Which conditions is it compromised in?
sickle cell anemia
What is the average lifespan of RBCs?
What is anisocytosis?
variation in the size of RBCs
What is poikilocytosis?
variation in the shapes of RBCs
A, B, Rh...which of these antigens have IgM antibodies against them and which have IgG antibodies?
A, B-->IgM antibodies
Rh-->IgG antibodies. The only one that causes problems for baby, b/c only IgG crosses the placenta
What type of reaction is it when there is transfusion that is incompatible?
Type II hypersensitivity (antibody-mediated)
When do you see erythroblastosis fetalis?
mom is exposed to Rh+ when she is Rh- during first pregnancy during delivery
second pregnancy, she has anti-Rh-IgG antibodies. these cross the placenta and attack the blood of the fetus
What are the features of erythroblastosis fetalis?
anemia b/c of hemolysis of RBCs from mom's Ab
hydrops fetalis (generalized fetal edema)
When should anti-RhD-immunoglobulin or RhoGAM be given to mom?
28 weeks (3rd tri) of 1st pregnancy
w/i 3 days of delivery