Flashcards in Endocrine1 Deck (32):
Which hormone stimulates bone and muscle growth?
Which hormone stimulates milk production? Milk secretion during lactation?
Which hormone increases blood glucose levels and decreases protein synthesis?
Where are oxytocin and vasopressin made?
Oxytocin-->released from post pit, but made in hypothalamus paraventricular nucleus
Vasopressin-->released from post pit, but made in hypothalamus supraoptic nucleus
Where is testosterone made?
testes leydig cells-men
What are the different forms of estrogen made?
Estrogen in men, testes.
Which receptors increase cAMP? Decrease it?
Increased by Gs, Decreased by Gi
Which hormones use cAMP messaging?
FLAT ChAMP calculates 2Gs
Which hormones use cGMP messaging?
Which receptors cause increase in IP3?
Cutesies HAV1 M&M (M1 & M3)
Which hormones cause increase in IP3?
Which hormones target intracellular steroid receptorS?
Which hormones use intrinsic tyrosine kinase receptors?
MAP kinase pathway
Which hormones use receptor-associated tyrosine kinase receptors?
What are some dopamine antagonists that can cause hyperprolactinemia?
antipsychotics (haloperidol, risperidone)
Where is somatostatin produced?
delta cells of pancreas
D cells of GI
What are some somatostatin analogs?
What are some indications for somatostatin analogs?
pituitary excess: acromegaly, thyrotropinoma, ACTH-secreting tumors
GI endocrine excess: zollinger-ellison syndrome, carcinoid syndrome, VIPoma, glucagonoma, insulinoma
Portal HTN: if you wanna reduce splanchnic circulation
bleeding peptic ulcers
What is Sheehan syndrome?
postpartum hemorrhage that leads to decreased blood flow to pituitary gland and partial infarction
decreased pituitary hormones released
get a galactorrhea, amenorrhea, fatigue, cold intolerance, weight gain
What is empty sella syndrome?
where the pituitary gland isn't sitting in the sella turcica where it should be
still some pituitary tissue left around...so usu asymptomatic
but if decreased pituitary hormones--associated symptoms
What are the hormones released from the ant pit?
What are the 2 secreting cell types found in the ant pit?
What is secreted from the basophils?
basophils--FSH, LH, ACTH, TSH
What is secreted from the acidophils?
What is the embryological origin of the ant pit and post pit?
ant pit: Rathke's pouch, ectodermal diverticulum
post pit: neuroectoderm, invagination of the hypothalamus
Which substances stimulate release of ADH?
Which substances inhibit release of ADH?
EtOH, ANF, decreased serum osmolarity
What is the downstream hormone of GH that is measured in suspected cases of acromegaly?
What increases GH release?
What decreases GH release?
Why is GH considered the opposite of insulin?
GH increases w/ hypoglycemia
prevents glucose uptake by cells