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Flashcards in Kidney-Glomerulus Deck (12):
1

Give the breakdown of water % in the body.

60% body is water
2/3 of that (40%) is ICF
1/3 (20%) is ECF.
75% of ECF is interstitial
25% of ECF is plasma.

2

What is the equation for renal clearance?

Cl=UV/P
u-urine conc'n
v-urine rate
p-plasma conc'n

3

What is the equation for excretion rate?

UV

4

Which substances estimate GFR?

Inulin and Creatinine (naturally made, but slightly secreted)
GFR=UxV/Px

5

Which substance estimates renal plasma flow?

PAH. It is fully filtered and secreted. RPF=UpahV/Ppah

6

What is the equation for filtration fraction? What is the normal %?

20%
FF=GFR/RPF

7

What is the equation for filtered load?

GFR X Pconc'n

8

What is the equation for reabsorption and secretion?

Reabsorbed=Filtered-Excreted
Secreted=Excreted-Filtered

9

Describe glucose reabsorption?

PCT via Na+/glucose co-transporter

10

When is the kidney's ability to absorb glucose compromised?

glucose starts to spill into urine ~200mg/dl in plasma
around 350 mg/dl no more can be reabsorbed.
**seen in diabetes.

11

Describe amino acid reabsorption in the kidney?

Na+ dependent at PCT. transporters for pos, neutral, and neg. charged AA.

12

What is hartnup disease?

aut recessive
don't have neutral AA transporters in PCT and enterocytes
Decreased tryptophan in body, can't make niacin (Vit B3)
Get pellagra symptoms:
Dermatitis
Diarrhea
Dementia
Death