Flashcards in Nephritic Syndromes Deck (14)
What are the main features of nephritic syndromes?
protein in urine
Acute post-strep glomerulonephritis...Describe the images on biopsy?
Light microscopy--glomeruli enlarged and hyper cellular and neutrophils up in there.
IF--lumpy bumpy IgG, IgM, C3 deposition along GBM and mesangium. GRANULAR
EM--subepithelial humps under podocytes
What type of hypersensitivity reaction is acute post-strep glomerulonephritis? Common presentation? Would antibiotics at the time of strep infection prevent this?
Type III hypersensitivity
children, 2 weeks after strep pharyngitis or skin infection
cola-colored urine, edema
No, b/c autoimmune. But antibiotics do prevent acute rheumatic fever and heart dx.
Which substances in blood indicate post-strep glomerulonephritis?
C3 decreased b/c consumed in deposition
anti-streptolysin O may be increased if after pharyngitis (but not skin infection)
in all types of strep infection--elevation anti-DNAse B
What is the image of rapidly progressive glomerulonephritis?
crescent moon shape
deposits of fibrin and plasma proteins
Which diseases can result in rapidly progressive glomerulonephritis?
Goodpasture--Type II (linear)
Wegener (granulomatosis w/ polyangitiis)
What can help distinguish wegener from microscopic polyangitiis rapidly progressing glomerulonephritis?
microscopic polyangitiis -- + p-ANCA (MPO-ANCA)
Diffuse proliferative glomerulonephritis is most often caused by what? What does it look like on biopsy?
Light micro: wire looping of capillaries
EM: subendothelial & intramembranous IgG and C3 deposits
Which 2 types of nephritic syndromes can present w/ proteinuria>3.5 g lookin like nephrotic?
diffuse proliferative glomerulonephritis
What does IgA nephropathy look like on biopsy?
LM: mesangial proliferation
EM: mesangial immune complexes
IF: IgA deposits in the mesangium.
Which syndrome is IgA nephropathy a part of? Presentation?
often post-URI or post-gastroenteritis (places w/ IgA)
Henoch Schonlein Purpura
What are the main features of Henoch Schonlein purpura?
What are the main features of Alport syndrome?
can't see, can't pee, can't hear high C.
X-linked disorder of Type IV collagen