Lipids Flashcards
Where does fatty acid synthesis take place? WHich special shuttle is required?
cytoplasm of hepatocytes citrate shuttle (sytrate, synthesis)
Where does fatty acid degradation take place? Which special shuttle is required?
in the mitochondrial matrix
transferred via carnitine shuttle (carnage of fatty acids)
What does fatty acid synthesis begin with? Rate limiting enzyme?
begins with acetyl coa
uses acetyl coa carboxylase
What are the basic important things about fatty acid degradation?
**happens in mitochondrial matrix
**beta oxidation–>acyl CoA–>TCA or ketone bodies
Rate limiting enzyme: carnitine acyltransferase 1 or carnitine palmitoyltransferase 1
What does cholesterol synthesis begin with ?
Acetyl CoA
In what way do statins inhibit HMG coa reductase?
competitively reversibly
What does Apo E do? Which things is it found on?
mediates remnant uptake
everything except LDL
What does ApoA-1 do Which things is it found on?
activates LCAT
HDL
Chylomicron
What does Apo CII do? What is it found on?
lipoprotein lipase cofactor
Chylomicron, VLDL, HDL
What does ApoB48 do? What is it found on?
ticket out of the intestine for the chylomicrons
found on chylomicron and chlymicron remnant
What does ApoB100 do? What is it found on?
binds LDL receptors, ticket out of liver
VLDL, IDL, LDL
What’s the deal with chylomicrons?
mainly TG
secreted by intestinal epithelial cells (ApoB48)
take TGs to peripheral tissues
remnant takes cholesterol to liver
What’s the deal with VLDL?
secreted by the liver (ApoB100)
delivers TG to peripheral tissue
What’s the deal with IDL?
formed after degradation of VLDL
takes TGs and cholesterol to liver
What’s the deal with LDL?
takes hepatic cholesterol to peripheral tissues
