Autoimmune Diseases

Question 1

SLE (systemic lupus erythematosus) is associated with what type of autoantibodies?

Answer 1

“vast array”

Question 2

What type of factors can cause someone to be more likely to develop SLE?

Answer 2

Family patterns, HLA-DQ
X chromosomes - females
UV light

Question 3

HLA-DQ is associated with?

Answer 3

SLE

Question 4

What immune mechanisms are involved with SLE?

Answer 4

1. B cells and CD4+ T cells

2. Antigen-Antibody complex (Type III)

Question 5

SLE has a tendency for what population?

Answer 5

Younger females

Question 6

Physical exam finding for SLE?

Answer 6

Butterfly (Malar) rash on the face

Question 7

Butterfly (malar) rash on the face is associated with?

Answer 7

SLE

Question 8

What are some other symptoms of SLE?

Answer 8

Hemolytic - Anemia/Thrombocytopenia
Renal damage
Fatigue, Fever
Arthritis

Question 9

Anemia, Renal damage, Arthritis, Fatigue, Fever?

Answer 9

SLE

Question 10

Most common subtype of SLE?

Answer 10

Type IV (Diffuse Nephritis)

Question 11

Are patients symptomatic and if so, list a few symptoms, with Diffuse Nephritis (IV)?

Answer 11

Yes - proteinuria, hematuria

Question 12

What heart problem is associated with Diffuse Nephritis (IV)?

Answer 12

Libman-Sacks Endocarditis

Question 13

What is Libman-Sacks Endocarditis?

Answer 13

• Heart condition associated with Diffuse Nephritis
  = Fibrin deposits on the heart valves
  – Not infective, but can embolize

Question 14

What artery disease are those with Diffuse Nephritis likely to get?

Answer 14

Coronary A. Disease

Question 15

What cell is usually seen with SLE?

Answer 15

L-E cell

- Neutrophil/Macrophage that has ingested nucleus of a damaged cell

Question 16

What is an L-E cell?

Answer 16

Neutrophil/Macrophage that has ingested nucleus of a damaged cell
- Seen with SLE/Diffuse Nephritis

Question 17

What do Glomeruli show with Diffuse Nephritis?

Answer 17

Proliferation of cells and immune complex deposits

Question 18

2 types of SLE?

Answer 18

1. Discoid Lupus Erythematosus

2. Drug-Induced Lupus Erythematosus

Question 19

Symptoms with Discoid Lupus Erythematosus?

Answer 19

Discoid rash on the face/scalp

Question 20

Discoid rash on the face/scalp

Answer 20

Discoid Lupus Erythematosus

Question 21

What tests will be (+)/(-) with Discoid Lupus Erythematosus?

Answer 21

(+) ANA
(+) Immunoflourescence
(-) Anti-DS DNA

Question 22

(+) ANA
(+) Immunofluorescence
(-) Anti-DS DNA

Answer 22

Discoid Lupus Erythematosus

Question 23

Symptoms with Drug-Induced Lupus Erythematosus?

Answer 23

Discoid rash, joint aches, fever, hematologic disease

Question 24

Symptoms with Drug-Induced Lupus Erythematosus?

Answer 24

Discoid rash, joint aches, fever, hematologic disease

Question 25

What causes Drug-Induced Lupus Erythematosus?

Answer 25

Medications | - Stop the medications and it will resolve

Question 26

What tests will be (+)/(-) with Drug-Induced Lupus Erythmatosus?

Answer 26

(+) ANA (+) Immunofluorescence (+) Anti-Histone Ab

Question 27

(+) Anti-Histone Antibody indicates?

Answer 27

Drug-Induced Lupus Erythematosus

Question 28

What occurs with Sjogren Syndrome?

Answer 28

Lacrimal and Salivary gland destruction

Question 29

Lacrimal and Salivary gland destruction

Answer 29

Sjogren Syndrome

Question 30

What cells are involved with Sjogren Syndrome and what will eventually result?

Answer 30

B and T cells cause inflammation and damage that will result in Fibrosis

Question 31

Anti-RO/ss-B and Anti-La/ss-A indicate?

Answer 31

Sjogren Syndrome

Question 32

Symptoms of Sjogren Syndrome?

Answer 32

Dry eye and Dry mouth with difficulty swallowing

Question 33

Dry eye and dry mouth with trouble swallowing is seen with?

Answer 33

Sjogren Syndrome

Question 34

Sjogren Syndrome causes dry mouth. What other things can be seen in the mouth?

Answer 34

Root caries | Smooth tongue with Candida yeast infection

Question 35

What other diseases can Sjogren Syndrome cause?

Answer 35

Pulmonary fibrosis | Lymphoma

Question 36

What is Systemic Sclerosis?

Answer 36

Fibrosis throughout the body, especially skin, GI, kidneys

Question 37

Fibrosis throughout the body with collagen deposition?

Answer 37

Systemic Sclerosis

Question 38

Main physical finding with Systemic Sclerosis?

Answer 38

Sclerodactyly

Question 39

What can Sclerodactyly progress to?

Answer 39

Raynauds - necrotic fingers

Question 40

Subtupe of Systemic Sclerosis?

Answer 40

CREST syndrome

Question 41

Symptoms of CREST syndrome?

Answer 41

``` C - calcium deposits R - raynaud fingers E - esophageal dysfunction S - sclerodactyly T - telangiectasis ```

Question 42

Telangiectasis

Answer 42

Red marks on skin | - Seen with CREST syndrome

Question 43

Symptoms of CREST syndrome?

Answer 43

``` C - calcium deposits R - raynauds fingers E - esophageal dysfunction S - sclerodactyly T - telangiectasis ```

Question 44

What do plasma cells produce with IgG4-related disease?

Answer 44

IgG4

Question 45

IgG4-related disease symptoms?

Answer 45

- Fibrosis - Scarring - Irreversible damage

Question 46

IgG4-related disease affects?

Answer 46

Many organs and is a process used by many disease

Question 47

IgG4-related disease symptoms?

Answer 47

- Fibrosis - Scarring - Irreversible damage