Hematopoietic Disorders

Question 1

Absolute Number

Answer 1

Actual number, not a percentage

Question 2

Anemia

Answer 2

Decreased RBCs or Hb

Question 3

Polycythemia

Answer 3

Increased RBCs or Hb

Question 4

Thrombopenia

Answer 4

Decreased platelets

Question 5

Thrombocythemia

Answer 5

Increased platelets

Question 6

Leukocytosis

Answer 6

Increased WBCs

Question 7

Leukopenia

Answer 7

Decreased WBCs

Question 8

Lymphocytosis

Answer 8

Increased lymphocytes

Question 9

Lymphopenia

Answer 9

Decreased lymphocytes

Question 10

Neutropenia

Answer 10

Decreased neutrophils

Question 11

Neutrophilia

Answer 11

Increased neutrophils

Question 12

Eosinophilia

Answer 12

Increased eosinophils

Question 13

Pancytopenia

Answer 13

Decreased ALL cell lines

Question 14

Decreased ALL cell lines

Answer 14

Pancytopenia

Question 15

MCV

Answer 15

Average volume of RBCs

Question 16

MCV less than 80 means?

Answer 16

Microcytic or Iron deficient Anemia

Question 17

MCV greater than 100 means?

Answer 17

Macrocytic Anemia

Question 18

MCH

Answer 18

Average mass of Hb

Question 19

MCHC

Answer 19

Concentration of Hb in a given volume

Question 20

RPI

Answer 20

Corrected reticulocyte % based on RBC volume

Question 21

Anisocytosis

Answer 21

Variation in size

Question 22

Variation in size

Answer 22

Anisocytosis

Question 23

Poikilocytosis

Answer 23

Variation in shape

Question 24

Variation in shape

Answer 24

Poikilocytosis

Question 25

Symptoms of iron deficient anemia?

Answer 25

Fatigue, headaches, pale skin, cold feet and hands, arrythmias

Question 26

What are 3 causes of iron deficient anemia?

Answer 26

1. Dietary lack of iron 2. Impaired absorption 3. Chronic blood or iron loss - distance running

Question 27

Lab values of MCV, MCH, MCHC, RBC and RDW with iron deficient anemia

Answer 27

DECREASED MCV, MCH, MCHC, RBC | INCREASED RDW

Question 28

What test will help to confirm a diagnosis?

Answer 28

Peripheral blood smear

Question 29

A MCV that is normocytic (80-100) then tests?

Answer 29

Reticulocyte count

Question 30

If reticulocyte count is LOW with normocytic MCV what does that indicate?

Answer 30

Decreased production

Question 31

If reticulocyte count is HIGH with normocytic MCV what does that indicate?

Answer 31

Increased destruction

Question 32

What 3 things can cause a Macrocytic MCV - Greater than 100?

Answer 32

1. B12 deficiency 2. Folate deficiency 3. Alcoholic liver disease

Question 33

B12 and Folate deficiency cause?

Answer 33

Macrocytic or Megaloblastic anemia

Question 34

Anemia caused by increased red cell loss causes what 2 things?

Answer 34

1. Increased reticulocytes | 2. Erythroid hyperplasia of bone marrow

Question 35

Most common nutritional deficiency in the world?

Answer 35

Iron

Question 36

Iron deficiency causes inadequate ____ synthesis

Answer 36

Hemoglobin

Question 37

With Compensatory erythropoisis and Asplenia, ____ RBCs can be seen

Answer 37

Nucleated

Question 38

Aplastic Anemia has a ____ bone marrow

Answer 38

Hypocellular

Question 39

Aplastic Anemia involves decreased?

Answer 39

Hematopoiesis

Question 40

4 causes of Neutrophilia?

Answer 40

Bacterial infection Medication Smoking Physical stress

Question 41

Besides an infection, what can cause Neutrophilia?

Answer 41

Medication Smoking Physical stress

Question 42

With a bacterial infection, what type of shift is seen?

Answer 42

Left shift | = Increased band cells

Question 43

WBC count greater than 50K with increased neutrophils and no evidence of leukemia?

Answer 43

Leukemoid reaction

Question 44

What can cause Neutropenia?

Answer 44

Drugs

Question 45

What can cause Lymphocytosis?

Answer 45

EBV or other viral infection | Pertussis bacteria

Question 46

Less than 20K platelets puts you at risk for?

Answer 46

Spontaneous intracranial bleeding

Question 47

Less than 100K platelets should avoid?

Answer 47

High risk surgeries

Question 48

What would the bone marrow show with the leukemoid reaction?

Answer 48

Mature bone marrow WITHOUT an increase in blasts

Question 49

What specific marker is elevated with the leukemoid reaction?

Answer 49

LAP

Question 50

Leukemia has majorly increased?

Answer 50

WBCs

Question 51

CML

Answer 51

Chronic Myelogenous Leukemia

Question 52

Who typically gets CML?

Answer 52

Adults

Question 53

The WBC count is usually around ______ for CML

Answer 53

100,000

Question 54

What are the 3 phases of CML?

Answer 54

Chronic phase Accelerated phase Blast phase

Question 55

Describe the cells seen with CML?

Answer 55

At first, a spectrum of differentiated cells | -- At the blast stage (towards end) = more than 20% blasts

Question 56

AML

Answer 56

Acute Myeloid Leukemia

Question 57

At what age does AML peak in incidence?

Answer 57

60

Question 58

Describe the cells seen with AML?

Answer 58

Greater than 20% immature myeloid blasts

Question 59

What other symptoms can AML present with?

Answer 59

Anemia/thrombocytopenia/neutropenia

Question 60

CLL

Answer 60

Chronic Lymphocytic Leukemia

Question 61

Who typically gets CLL?

Answer 61

Older adults

Question 62

Symptoms of CLL?

Answer 62

Lymphadenopathy | Hepatosplenomegaly

Question 63

ALL

Answer 63

Acute Lymphoblastic Leukemia

Question 64

Who typically gets ALL?

Answer 64

Children

Question 65

Describe the cells seen with ALL?

Answer 65

Numerous blasts

Question 66

What conditions are Auer rods seen in cells?

Answer 66

AML | CML