Mediators of Inflammation (3) Flashcards

(29 cards)

1
Q

What secretes Histamine?

A

Mast Cells
Basophils
Platelets

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2
Q

3 actions of Histamine?

A

VASODILATION
Increased vascular permeability
Endothelial activation

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3
Q

Prostaglandins and Leukotrienes are produced from?

A

Arachidonic Acid

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4
Q

Arachidonic Acid creates _____ to create Prostaglandins

A

Cyclooxygenase

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5
Q

3 actions of Prostaglandins?

A

Vasodilation
Fever
Pain

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6
Q

What can inhibit Cyclooxygenase and thus prostaglandin formation?

A

COX inhibitors

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7
Q

Arachidonic Acid creates _____ to create Leukotrienes

A

5-lipoxygenase

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8
Q

2 actions of Leukotrienes?

A

Bronchospasm

Increased Vascular permeability

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9
Q

5-lipoxygenase can create 12-lipoxygenase to create ____

A

Lipoxins

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10
Q

Action of Lipoxins?

A

INHIBIT NEUTROPHIL adhesion and chemotaxis

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11
Q

TNF action

A

Increase Adhesion molecules

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12
Q

IL-1 actions

A

Increase Adhesion molecules

Fever

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13
Q

IL-17 action

A

Recruit neutrophils and monocytes

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14
Q

IL-12 action

A

Increase production of IFNgamma

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15
Q

IFNgamma action

A

Activate macrophages

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16
Q

Proteins that act as chemoattractants for leukocytes

17
Q

What activates C3 in the complement cascade?

A

C3 convertase

18
Q

Actions of the complement cascade

A

Increased vascular permeability
Phagocytosis
Chemotaxis

19
Q

What controls the complement system?

20
Q

If there is a deficiency in C1 inhibitor, what results?

A

Hereditary Angioedema

21
Q

Serous Inflammation

A

Cell poor fluid into spaces (NO microbes or leukocytes)

22
Q

Fibrinous Inflammation

A

Large molecules can pass through the endothelium due to increased permeability

23
Q

Fibrinous Inflammation is characteristic infammation of?

A

Inflammation of lining of body cavities

24
Q

Purulent Inflammation

A

Production of pus (neutrophils, cell debris, microbes)

25
Purulent Inflammation is seen with what type of necrosis?
Liquefactive
26
Pyogenic
Pus producing bacteria
27
Ulcer
Sloughing of inflamed necrotic tissue
28
3 outcomes of Acute Inflammation?
1. Resolution 2. Fibrosis = loss of function 3. Chronic Inflammation
29
Fibrosis
Loss of function