RNA Viruses Flashcards
What is the #1 RNA virus that causes a cold?
Rhinovirus
What is the #1 RNA virus that causes childhood pneumonia?
Respiratory Syncytial Virus (RSV)
What cells are formed with Respiratory Syncytial Virus (RSV)?
Giant cells
What does Metapneumovirus cause in children?
Pneumonia
What does Parainfluenza cause?
Croup with infection of the larynx/bronchus
“barking cough” is seen with what virus?
Parainfluenza
– Causes croup and infection of larynx/bronchus
Coronavirus causes?
Colds and Atypical pneumonia
SARS
Severe Acute Respiratory Syndrome
What are 5 respiratory viruses?
Rhinovirus Respiratory Syncytial Virus (RSV) Metapneumovirus Parainfluenza Coronavirus
Influenza has 2 ____ virulence factors
Glycoprotein
What are the virulence factors for Influenza?
- Hemagglutinin
2. Neuraminidase
What are the virulence factors for Influenza?
- Hemagglutinin
2. Neuraminidase
Action of Hemagglutinin?
- Virulence factor of Influenza
= Binds to sialic acid receptors
Action of Neuraminidase?
- Virulence factor of Influenza
= Disrupts mucin barrier
Symptoms of Influenza infection?
Fever, rhinorrhea, cough, myalgias
Antigenic Drift
Mutations that result in small changes in Hemagluttinin and Neuraminidase
What type of disease does Antigenic Drift cause and why?
Milder infection because the previous antibodies still partially recognize the modified Hemagluttinin and Neuraminidase
Antigenic Shift
Trading of RNA segments between viruses resulting in completely NEW hemagluttinin and Neuraminidase
What type of disease does Antigenic Shift cause and why?
Everyone is susceptible because it creates completely new virulence factors
MMR vaccine protects against?
Measles
Mumps
Rubella
Cascade of symptoms of Measles infection?
- Fever and cough
- Koplik’s spots
- Head to toe maculopapular rash
- Possible pneumonia
Koplik’s spots?
Oral lesions that are white and red on the periphery
- seen with Measles
Main symptoms of Measles?
- Koplik’s spots (white oral lesions with red periphery)
- Head to toe maculopapular rash
What is Subacute Sclerosing Panencephalitis?
Progressive neurologic disease
= forgetfullness, hallucinations and distractibility
– later symptom of measles infection
