Miscellaneous topics 7 Flashcards

1
Q

Deflation of the pneumatic tourniquet during orthopedic surgery is expected to increase:
a. blood pressure
b. mixed venous oxygen saturation
c. end-tidal carbon dioxide
d. blood pH

A

c.

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2
Q

______________________ increases intramedullary pressure in the bone and this can produce microemboli that travel to the lungs.

A

Methyl methacrylate

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3
Q

Methyl methacrylate that produces microemboli that can travel to the lungs can result in

A

V/Q mismatch and potentiate right heart failure

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4
Q

Residual methyl methacrylate can enter the systemic circulation where it causes

A

bradycardia, dysrhythmias, systemic hypotension, pulmonary hypertension, hypoxia, and cardiac arrest

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5
Q

Methyl methacrylate entering the systemic circulation is known as

A

bone cement implantation syndrome (BCIS)

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6
Q

__________ is a recognized complication of long bone trauma

A

Fat embolism syndrome

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7
Q

The triad of fat embolism syndrome includes

A

respiratory insufficiency, neurologic changes, and a petechial rash

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8
Q

To reduce the risk of limb ischemia when using a pneumatic tourniquet, the maximum inflation time is

A

two hours

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9
Q

When used for a bier block, the tourniquet must remain inflated for at least

A

20 minutes after LA is injected

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10
Q

Premature release of LA after a bier block can lead to

A

seizures and/or cardiac arrest

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11
Q

Under general anesthesia, tourniquet pain manifests as

A

hypertension and tachycardia

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12
Q

Deflating the pneumatic tourniquet causes a

A

redistribution of circulating blood volume and exposes the body to the washout of metabolites that accumulated during limb ischemia

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13
Q

___________ is associated with the highest risk of bone implementation syndrome

A

Hip arthroplasty

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14
Q

In the awake patient under regional anesthesia, the first signs of BCIS are usually

A

dyspnea and AMS

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15
Q

Under GA, the first sign of BCIS is usually

A

a decreased EtCO2

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16
Q

First line treatment of BCIS is

A

100% FiO2
IV hydration
phenylephrine for hypotension

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17
Q

Risk factors for fat emboli syndrome include

A

pelvic fracture
femoral fracture
instrumentation of the femoral medullary canal

18
Q

Releasing the tourniquet produces transient changes that include

A

increased EtCO2
decreased core body temperature
decreased blood pressure
decreased SvO2 (SaO2 is usually normal)
metabolic acidosis

19
Q

Tourniquet pain is transmitted by

A

C fibers

20
Q

What is the best way to treat intractable pain when using an orthopedic tourniquet in a patient with a neuraxial block?

A

convert to GA. this type of pain is unresponsive to analgesics

21
Q

All of the following are associated with Samter’s triad EXCEPT:
a. allergic rhinitis
b. bronchospasm
c. nasal polyps
d. hypertension

A

d. Hypertension

22
Q

Inhibition of Cox-1 enzyme does the following three things:

A

impairs platelet function
causes gastric irritation
reduces renal blood flow

23
Q

Inhibition of the COX-2 enzyme produces

A

analgesia
anti-inflammation
antipyretic effects

24
Q

Aspirin inhibits

A

COX-1 & COX-2 irreversibly

25
Q

Aspirin-exacerbated respiratory disease (Samter’s triad) refers to the combination of

A

asthma
allergic rhinitis
nasal polyps
which can cause life threatening bronchospasm following administration

26
Q

Toradol 30 mg IV is equivalent to morphine ________

A

10 mg IV

27
Q

Acetaminophen is __________ an NSAID

A

NOT!

28
Q

The most common cause of acute liver failure in the US is

A

acetaminophen

29
Q

The max dose of acetaminophen is

A

4g/day

30
Q

What NSAIDs have cox 2 selective inhibition?

A

Celecoxib
any drug that ends with -coxib

31
Q

What are the key CV complications of NSAIDs?

A

increased risk of HTN, MI & HF (COX 2 inhibitors> Cox-1 inhibitors)

32
Q

What are the key hematologic complications of NSAIDs?

A

platelet inhibition–> increased bleeding risk

33
Q

Ketorolac can only be taken for

A

5 days

34
Q

Aspirin toxicity can cause a

A

gap metabolic acidosis

35
Q

List 6 drugs that inhibit the COX-2 pathway.

A

aspirin
ibuprofen
naproxen
ketorolac
diclofenac
indomethacin

36
Q

Herbal medicines that increase bleeding tendencies include

A

garlic
ginger
ginko biloba
ginseng

37
Q

Are herbal medicines contraindications to regional anesthesia?

A

no as long as the patient is not on other anticoagulant medications

38
Q

Herbs that reduce MAC include

A

kava kava & valerian

39
Q

Complications of ephedra-containing compounds (Ma Huang) include

A

SNS effects
catecholamine depletion
increased risk of serotonin syndrome when co-administered with MAOIs

40
Q

St. John’s wort may

A

prolong duration of anesthetic agents & lead to serotonin syndrome with interaction with MAOIs and meperidine