Coagulation 8

Question 1

Triggers of sickle cell crisis include: (select 2)
a. alkalosis
b. hyperthermia
c. pain
d. dehydration

Answer 1

c. & d.

Question 2

Sickle cell disease is a _________ disorder that affects __________

Answer 2

inherited; erythrocytes

Question 3

Sickled cells are more prone to _________

Answer 3

hemolysis and removal by the spleen

Question 4

What is the average lifespan of sickled cells compared to normal cells

Answer 4

12-17 days vs. 120 days

Question 5

______________ leads to sickling

Answer 5

deoxygenation of HgbS

Question 6

Sickling causes the RBCs to ___________ which causes __________

Answer 6

clump together; mechanical obstruction of the microvasculature in the vital organs and joints

Question 7

What factors can trigger a sickle-cell crisis?

Answer 7

pain
hypothermia
hypoxemia
acidosis
dehydration

Question 8

Complications of sickle cell crisis include

Answer 8

vaso-occlusive crisis, acute chest syndrome, & sequestration crisis

Question 9

The most common manifestation of sickle cell disease is

Answer 9

vaso-occlusive crisis

Question 10

Treatment of vaso-occlusive crisis includes

Answer 10

analgesics and hydration

Question 11

As a general rule, patients with sickle cell ______ do not advance to crisis. _________ is a key exception to this rule.

Answer 11

TRAIT; Severe hypoxemia

Question 12

____________ reduces the incidence and severity of vaso-occlusive crisis

Answer 12

Hyroxyurea

Question 13

Acute chest syndrome is caused by

Answer 13

thrombosis, embolism, and infection

Question 14

Diagnosis of acute chest syndrome includes

Answer 14

new lung infiltrates on the CXR and at least one of the following: chest pain, cough, dyspnea, or wheezing

Question 15

Potential causes of acute chest syndrome include

Answer 15

hypoventilation
narcotics
splinting
pain

Question 16

Sequestration crisis occurs when the

Answer 16

spleen removes RBCs from the circulation at a faster rate than the bone marrow produces them

Question 17

Sequestration crisis leads to

Answer 17

anemia & hemodynamic instability

Question 18

Aplastic crisis is usually caused by

Answer 18

viral infection

Question 19

Sickle cell is associated with

Answer 19

asthma (50% of patients)
pHTN (10% of patients)

Question 20

patients with sickle cell disease can also develop

Answer 20

pneumococcal disease (children at highest risk)