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MTAP 1 Clinical Chemistry > 2.4.3 Proteins (Serum protein Fractions) > Flashcards

2.4.3 Proteins (Serum protein Fractions) Flashcards

1
Q

Indicator of malnutrition

a. Pre albumin
b. Albumin

A

a

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2
Q

Major contributor to plasma oncotic/osmotic pressure

a. Pre albumin
b. Albumin

A

b

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3
Q

Binds/Transport T4 as Transthyretin/TBPA

a. Pre albumin
b. Albumin

A

a

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4
Q

Forms a complex with retinol Binding protein (RBP)

a. Pre albumin
b. Albumin

A

a

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5
Q

Second most abundant protein fraction in CSF

a. Pre albumin
b. Albumin

A

a

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6
Q

General transport protein

a. Pre albumin
b. Albumin

A

b

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7
Q

Decrease levels in Nephrotic syndrome, protein-losing enteropathy and liver disease

a. Pre albumin
b. Albumin
c. Haptoglobulin
d. Transferrin

A

b

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8
Q

Most abundant fraction

a. Pre albumin
b. Albumin

A

b

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9
Q

This is not distinct in Serum electrophoresis

a. Pre albumin
b. Albumin
c. Immunoglobulin
d. CRP

A

a

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10
Q

Absence of albumin

a. Analbuminemia
b. bisalbuminemia

A

a

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11
Q

Albumin

Negative APR: Decrease in_______________

a. Transport of substance
b. Inflammation
c. Analytes
d. None of the above

A

b

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12
Q

The following are Alpha 1 protein except:

  • 𝜢-Fetroprotein
  • 𝜢1- Antitrypsin
  • 𝜢1- Acid glycoprotein
  • 𝜢1-Antichymotrypsin
  • Gc-globulin
  • Haptoglobulin
A

Haptoglobulin ( 𝜢2)

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13
Q

Increase levels in amniotic fluid NEURAL TUBE DEFECT

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

a

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14
Q

Acute Phase Reactant

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

b and c

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15
Q

Transport Vit D

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

e

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16
Q

Protease inhibitor

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

b and d

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17
Q

Binds progesterone and some drugs

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

c

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18
Q

Major component for alpha 1 region?

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

b

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19
Q

Increase level in adult serum which may cause Hepatocellular CA/Liver cancer

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

a

20
Q

Deficiency is associated with SERPINA 1 gene mutation and causes juvenile hepatic cirrhosis and pulmonary emphysema

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

b

21
Q

Binds prostate specific antigen

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

d

22
Q

Decrease level may lead to abnormal calcium level

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

e

23
Q

Negatively charged even in in pH, has a very high CHO content

a. 𝜢-Fetroprotein
b. 𝜢1- Antitrypsin
c. 𝜢1- Acid glycoprotein
d. 𝜢1-Antichymotrypsin
e. Gc-globulin

A

c

24
Q

The following are Alpha 2 protein except:

  • 𝜢2-Macroglobulin
  • Hepatoglobulin
  • Ceruplasmin
  • Transferrin
  • Hemopexin
A

Transferrin and Hemopexin

25
Q

A Protease inhibitor and the largest non-Ig protein

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

a

26
Q

The following are PROTEASE INHIBITOR except:

  • 𝜢2-Macroglobulin
  • 𝜢1-Antitrypsin
  • 𝜢1- antichymotrypisin
  • 𝜢1- Acid glycoprotein
A
  • 𝜢1- Acid glycoprotein
27
Q

An acute Phase reactant that BINDS to hemoglobin to PRESERVE IRON

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

b

28
Q

An acute phase reactant that is a binding protein and has oxidase activity

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

c

29
Q

Increase ten-fold in Nephrotic syndrome and protein-losing enteropathy

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

a

same with albumin but decrease

30
Q

Decrease level seen in hemolytic disorders/Intravascular hemolysis

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

b

31
Q

Decrease level seen in Wilson’s disease

a. 𝜢2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin

A

c

32
Q

The following are acute phase reactant except:

  • Haptoglobulin
  • Ceruloplasmin
  • 𝜢𝟏- Antitrypsin
  • 𝜢𝟏 - Acid glycoprotein
A

None

33
Q

Serve as both APR and protease inhibitor

a. Haptoglobulin
b. Ceruloplasmin
c. 𝜢𝟏- Antitrypsin
d. 𝜢𝟏 - Acid glycoprotein

A

c

34
Q

The following are beta globulins except:

  • Transferrin
  • C3 complement
  • Hemopexiin
  • Ξ’2-microglobulin
  • CRP
A

CRP

35
Q

Immune response

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

b

36
Q

Transports iron

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

a

37
Q

What is the difference between transferrin and haptoglobin?

A

Haptoglobulin: Preserves iron
Transferrin: Transport iron

38
Q

Binds heme

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

c

39
Q

Component of MHC or HLA molecules

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

d

40
Q

Increase level seen in Iron deficiency anemia

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

a

41
Q

Mos abundant complement component?

A

C3 complement

42
Q

Decrease level in intavascular hemolysis

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

c

43
Q

Use to measure GFR

a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ’2-microglobulin

A

d

44
Q

The followin are gamma protein except:

  • C-reactive protein
  • IgG
  • IgM
  • Immunoglobulins
A

None

45
Q

Increased up to 1000 times i inflammatory states; hs CRP used as marker for cardiovascular disorder

a. C-reactive protein
b. Immunoglobulins

A

a

46
Q

Immunoglobulins are produced by what cell?

A

Plasma cell/Memory cell/B cell

47
Q

Extra bands is seen if specimen is:

Plasma = __________
- Forms a band between beta and _______ region

Hemolyzed = Hemoglobin
- Forms a band between alpha 2 and beta

A

Fibrinogen
- gamma region

MTAP 1 Clinical Chemistry (97 decks)

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