3.2.3.1 Clinical Enzymology (Aminotransferases/Transaminases)

Question 1

Tissue sources includes:
- Liver

a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT

Answer 1

d

Question 2

Tissue sources includes:
- Liver
- Heart
- Skeletal Muscle

a. Creatinine kinase
b. Lactate dehydrogenase
c. AST / SGOT
d. ALT / SGPT

Answer 2

c

Question 3

Acute hepatocellular disorders (More specific, higher and more sustained elevation

a. AST / SGOT
b. ALT / SGPT

Answer 3

b

Question 4

Due to ALT having higher elevation and sustained, the half-life of this is ________

Answer 4

longer

Question 5

De ritis ratio:

a. <1 (AST/ALT)
b. <2 (AST/ALT)
c. <3 (AST/ALT)
d. <4 (AST/ALT)

Answer 5

a

If ALT is higher, the lower the ratio

Question 6

Pronounced diagnosis in AST is usually what organ?

a. Liver
b. Heart
c. Skeletal muscle

Answer 6

a and b

Question 7

AST:

Acute hepatocellular disorders, circulatory collapse, myocardial infarction

a. Pronounced
b. Moderate
c. Slight

Answer 7

a

Question 8

AST:

Muscular dystrophy

a. Pronounced
b. Moderate
c. Slight

Answer 8

b

Question 9

Release where there is tissue damage

a. Cytoplasmic AST
b. Mitochondrial AST

Answer 9

a

Question 10

Release when there extensive tissue damage

a. Cytoplasmic AST
b. Mitochondrial AST

Answer 10

b

Question 11

Increase in hepatic failure and alcoholic liver disease which is an exception to De ritis since it is Greater than 1

a. Cytoplasmic AST
b. Mitochondrial AST

Answer 11

b

Question 12

Has the longest half life among aminotransferase

a. Cytoplasmic AST
b. Mitochondrial AST
c. ALT

Answer 12

b

Question 13

The sequence of half-life in Aminotransferases from longest to shortest

a. ASTc
b. ALT
c. ASTm

Answer 13

c,b,a

Question 14

If mitochondrial AST is high, the De ritis ratio is High

T or F

Answer 14

T

Question 15

IF De ritis is more than 1 what is the clinical significance?

a. Hepatic failure
b. Alcoholic liver disease
c. All of the above

Answer 15

c