4.2.4.2 Major Hormones (Adrenal Hormones, Lab Diag) Flashcards
- Urine Free Cortisol collected over 24 HOURS
- Midnight Salivary Cortisol
- DEXAMETHASONE Suppression Test
- Plasma ACTH- requires use of PRE-CHILLED TUBE
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
b
- ACTH stimulation (Cortrosyn) test
- Insulin tolerance test
- Metyrapone test: FERRIMAN GALLWEY SCROING SYSTEN or SCALE
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
c
- Urine Homovanillic acid
- Vanillylmandelic acid
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
f
- Plasma Free Metanephrine / Normetanephrine
- CLONIDINE suppression test
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
e
- 21-Hydroxylase
- Plasma 17-hydroxyprogesterone and pregnanetriol
- Urinary Pregnanetriol
- 17-ketosteroids
- Scale used for grading HIRSUTISM:
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
d
- Urinary Potassium excretion
- Captopril suppression
- Upright PA/PRA ratio
- 18-Hydroxycorticosterone
a. Primary Aldosteronism
b. Cushing’s Syndrome
c. Addison’s disease (Primary hypoadrenalism)
d. Congenital adrenal hyperplasia
e. Phaeochromocytoma
f. Neuroblastoma
a
Pituitary: Cushing’s disease
Adrenal cortex: Cushing’s syndrome
T or F
T
Plasma cortisol: ↑
Plasma ACTH: ↓ or undetectable
HD-DST: No
a. Cushing Syndrome
b. Cushing Disease
c. Ectopic CS
a
Plasma cortisol: ↑
Plasma ACTH: ↑
HD-DST: Yes
a. Cushing Syndrome
b. Cushing Disease
c. Ectopic CS
b
Plasma cortisol: ↑↑
Plasma ACTH: ↑↑↑
HD-DST: Usually not suppressed
a. Cushing Syndrome
b. Cushing Disease
c. Ectopic CS
c
Dexamethasone does not suppress cortisol production in Cushing syndrome or primary Cushing.
T or F
T
For hypersecretory, the test is suppression and for hyposecretory, the test is stimulation.
T or F
T
congenital adrenal hyperplasia, the most common enzyme deficiency is the ___________
a. 21-Hydroxylase
b. 24-Hydroxylase
c. 22-Hydroxylase
a
congenital adrenal hyperplasia:
When deficient, blocked synthesis of aldosterone and cortisol happens which is why there is a shift in ______________
a. Androgen secretion
b. Estrogen secretion
c. Cortisol secretion
a
