What cell types are involved in chronic inflammation
Macrophages
Plasma cells
Lymphocytes
Fibroblasts
What is the outcome of chronic inflammation
features tissue or organ damage, (necrosis)
What is the clinical presentations of chronic inflammation
Loss of function
Weight loss
Not a specific sore bit
What are the two ways chronic inflammation appears
arising from acute inflammation
arising as a primary lesion
What are the steps in granulation tissue
Capillaries grow into mass
Plasma proteins (platelts)
Macrophages come from blood and tissue
fibroblasts lay down collagen to repair damaged tissue
crosslinking occurs pulling skin tighter together - narrowing
forming scar
When can fibrosis become a problem
Leads to chronic inflammation
Loss of functions in organs
What is granulation an outcome of and what can it lead to
Acute inflammation that can lead to Chronic inflammation
What are examples of chronic inflammation from acute inflammation
Acne Cholecystitis (inflammation of the gall bladder) Peptic ulcer Osteomyelitis (abscess in the bone) Fracture healing
How can chronic inflammation occur as a primary lesion
Due to autoimmune disease, as auto antibodies are directed against own cell tissue
Examples of autoimmune disease chronic inflammation
Thyroiditis,
Rheumatoid disease
Foreign body
What are factors that can cause primary chronic inflammatory response but not an immune response
material resistant to digestion
exogenous substances (eg sutures, hip replacement)
endogenous substances (eg. keratin, necrotic tissue)
granulomata inflammation
