Chronic Inflammation Flashcards Preview

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Flashcards in Chronic Inflammation Deck (11):
1

What cell types are involved in chronic inflammation

Macrophages
Plasma cells
Lymphocytes
Fibroblasts

2

What is the outcome of chronic inflammation

features tissue or organ damage, (necrosis)

3

What is the clinical presentations of chronic inflammation

Loss of function
Weight loss
Not a specific sore bit

4

What are the two ways chronic inflammation appears

arising from acute inflammation
arising as a primary lesion

5

What are the steps in granulation tissue

Capillaries grow into mass
Plasma proteins (platelts)
Macrophages come from blood and tissue
fibroblasts lay down collagen to repair damaged tissue
crosslinking occurs pulling skin tighter together - narrowing
forming scar

6

When can fibrosis become a problem

Leads to chronic inflammation
Loss of functions in organs

7

What is granulation an outcome of and what can it lead to

Acute inflammation that can lead to Chronic inflammation

8

What are examples of chronic inflammation from acute inflammation

Acne
Cholecystitis (inflammation of the gall bladder)
Peptic ulcer
Osteomyelitis (abscess in the bone)
Fracture healing

9

How can chronic inflammation occur as a primary lesion

Due to autoimmune disease, as auto antibodies are directed against own cell tissue

10

Examples of autoimmune disease chronic inflammation

Thyroiditis,
Rheumatoid disease
Foreign body

11

What are factors that can cause primary chronic inflammatory response but not an immune response

material resistant to digestion
exogenous substances (eg sutures, hip replacement)
endogenous substances (eg. keratin, necrotic tissue)
granulomata inflammation