Pathogen and host: Immunity Flashcards Preview

Medicine Term One > Pathogen and host: Immunity > Flashcards

Flashcards in Pathogen and host: Immunity Deck (26):
1

What capsule organism is resistant to phagocytosis

Strep pneumoniae

2

What organism is resistant to intracellular killing

Mycobacterium tuberculosis
Legionella pneumophila
Candida albicans (AIDS)

3

What is involved in monoclear phagocytic system

liver (clears bile to liver)
spleen (filters the blood)
lymph nodes (drains peripheral sites)

4

What is opsonisation

Organisms coated with antibody allowing immune system recognition,

5

In humeral response what is produced

antibodies (b cells)

6

In cellular response what is produced

T cells

7

What is an epitode

the part of an antigen molecule to which an antibody attaches itself

8

What does opsonisation allow

Increase in phagocyte efficiency

9

What are immunoglobulins

are the proteins with antibody activity

10

what are the 5 classes of immunoglobulins

1. IgG - Gamma heavy chains
2. IgM - Mu heavy chains
3. IgA - Alpha heavy chains
4. IgD - Delta heavy chains
5. IgE - Epsilon heavy chains

11

IgA

Initial defence in mucosal against pathogen agents

12

IgM

Expressed in the surface of B-cells promoting phagocytosis and activate the complement system

13

IgE

Allergy and helminth infection

14

IgG

Moat abundant, promote phagocytosis in plasma and activate the complement system

15

What immunoglobulins are needed in compliment system

IgG or IgM

16

What happens to B lymphocytes when the recognise specific epitope

differentiate into plasma cells

17

What kind of T helper cells do by lymphocytes need

CD4+

18

Whats the most important proteins out of the 20 complement proteins

c1 - c9

19

what specificity does;
monoclonal antibody
polyclonal antibody

Single epitope specificity
Multiple specificity

20

What does antibody do in an infection

neutralises bacterial toxins
neutralises viruses (stop virus in the blood)
prevents adherence of microorganisms
Induce phagocytosis

21

What does complement do to gram -

lysis

22

What happens to complement by products

chemotactic, attract further WBC

23

What happens in cell mediated immunity with t helper cells

Macrophage present antigen MCH2 to T helper cell CD4 inducing cytokines production, activating macrophages

24

What does humoral immunity induce

inflammation

25

T helper cells functions

Cell mediated immunity by activating macrophages
help B cells antibody response

26

What happens to cytotoxic T-cells (CD8)

Combine with MHC1 antigen and if detect host is infected, kills the cell