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Flashcards in Drug delivery system Deck (38):
1

What three factors determine the drug delivery system we use

The dose of the drug to be given
The frequency of administration
The timing of administration

2

What is a prodrug

synthesised inactive derivatives of an active drug metabolically activated after administration

3

What is the advantages of a prodrug

prolongation of action

4

What are methods of drug delivery

Oral
Sublingual
suppositories
pessaries
IV
Intramuscular
Transdermal - patches, percutaneous
Inhalation
carrier based drug delivery therapy

5

What is the benefit of oral suspension

dosage contained with small volume
insoluble
insoluble unpalatable drugs are better tolerated
rapid, especially in small intestine

6

What is the rate limiting step in absorption of oral tablets

dissolution

7

What does modified release tablet do

reduces rate of absorption allowing a slow but sustained release over a long period of time

8

Why is modified release useful

for disorders requiring prolonged therapy
maintaining drug levels within therapeutic range
reduces the need for frequenting dosing
improves compliance

9

What is the purpose of enteric coated tablets

delays disintegration until tablet reaches the small intestine

10

What is the two benefits of enteric coated tablets

Protects the stomach from the drug
protects the drug from the stomach

11

Example of a drug that can cause damage to the stomach

aspirin

12

Why is omeprazole enteric coated

to protect it from stomach acid

13

Where is oral tablets absorbed via

small intestine

14

What is the advantages of sublingual

bypasses first pass metabolism
small and dissolve under the tongue going straight into circulation

15

What route do suppositories follow

rectal

16

What are the advantages of suppositories

by pass first pass metabolism
useful for patients who cant swallow, young or old
treats local conditions

17

What is a pessaries is used to treat

thrush

18

What are the benefits of injection based delivery

fast systemic effect
bypass first pass metabolism
can administrate to unconscious patients
short half life therefore can continuously infuse

19

What are three types of injection based delivery

IV - into viens
IntraMuscular - into muscle
Subcutaneously - applied under the skin

20

Why is it beneficial that IV allows continually infusion

allows accurate control with narrow therapeutic index

21

How do you prevent toxicity of IV delivery

deliver it slowly

22

What is an disadvantage intramuscular

may be painful

23

example of intramuscular injection

Contraceptive

24

What are two different types of subcutaneous injections

Dermojet - needless injection used for mass inoculation
Pellet implantation - solid pellet implantation

25

Example of dermojet and pellet implantation

Insulin
testosterone

26

How is the drug absorbed in transdermal

diffuses by skin absorption

27

What are the different from of transdermal

adhesive patch
percutaneous - creams/ointments

28

What is the advantage of transdermal

By pass first pass metabolism
controlled level of drugs

29

Example of transdermal adhesive patches

HRT
Contraception
Nicotine
Opiates

30

What is an example of a local and systemic percutaneous

local - steroid
systemic - HRT

31

What is the advantages of inhalation

delivered directly to the lungs
rapid
little systemic absorption
reduced adverse reactions

32

What are different methods of carrier based drug delivery

monoclomal antibodies
Liposomal drug delivery
Nanoparticle based drug delivery
Genetic transfer system

33

What is the purpose of monoclonal antibodies

bind to cancer specific antigen and induce immune response to cancer cells

34

what is the advantaged of Liposomal drug delivery

reduced toxicity
enhanced efficiency

35

What is the advantage of nanotechnology

target precise location
therefore: more effective, specific
Reduce toxicity

36

what are nanoerythrosomes

resealed erythrocytes that carry proteins, enzymes and macromolecules

37

what can nanoerythrosomes treat

liver disease
parasitic infection
enzyme disease

38

What is genetic transfer

When viral replication is implicated and used for good