Drug delivery system Flashcards Preview

Medicine Term One > Drug delivery system > Flashcards

Flashcards in Drug delivery system Deck (38)
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1
Q

What three factors determine the drug delivery system we use

A

The dose of the drug to be given
The frequency of administration
The timing of administration

2
Q

What is a prodrug

A

synthesised inactive derivatives of an active drug metabolically activated after administration

3
Q

What is the advantages of a prodrug

A

prolongation of action

4
Q

What are methods of drug delivery

A
Oral 
Sublingual 
suppositories 
pessaries 
IV 
Intramuscular 
Transdermal - patches, percutaneous 
Inhalation 
carrier based drug delivery therapy
5
Q

What is the benefit of oral suspension

A

dosage contained with small volume
insoluble
insoluble unpalatable drugs are better tolerated
rapid, especially in small intestine

6
Q

What is the rate limiting step in absorption of oral tablets

A

dissolution

7
Q

What does modified release tablet do

A

reduces rate of absorption allowing a slow but sustained release over a long period of time

8
Q

Why is modified release useful

A

for disorders requiring prolonged therapy
maintaining drug levels within therapeutic range
reduces the need for frequenting dosing
improves compliance

9
Q

What is the purpose of enteric coated tablets

A

delays disintegration until tablet reaches the small intestine

10
Q

What is the two benefits of enteric coated tablets

A

Protects the stomach from the drug

protects the drug from the stomach

11
Q

Example of a drug that can cause damage to the stomach

A

aspirin

12
Q

Why is omeprazole enteric coated

A

to protect it from stomach acid

13
Q

Where is oral tablets absorbed via

A

small intestine

14
Q

What is the advantages of sublingual

A

bypasses first pass metabolism

small and dissolve under the tongue going straight into circulation

15
Q

What route do suppositories follow

A

rectal

16
Q

What are the advantages of suppositories

A

by pass first pass metabolism
useful for patients who cant swallow, young or old
treats local conditions

17
Q

What is a pessaries is used to treat

A

thrush

18
Q

What are the benefits of injection based delivery

A

fast systemic effect
bypass first pass metabolism
can administrate to unconscious patients
short half life therefore can continuously infuse

19
Q

What are three types of injection based delivery

A

IV - into viens
IntraMuscular - into muscle
Subcutaneously - applied under the skin

20
Q

Why is it beneficial that IV allows continually infusion

A

allows accurate control with narrow therapeutic index

21
Q

How do you prevent toxicity of IV delivery

A

deliver it slowly

22
Q

What is an disadvantage intramuscular

A

may be painful

23
Q

example of intramuscular injection

A

Contraceptive

24
Q

What are two different types of subcutaneous injections

A

Dermojet - needless injection used for mass inoculation

Pellet implantation - solid pellet implantation

25
Q

Example of dermojet and pellet implantation

A

Insulin

testosterone

26
Q

How is the drug absorbed in transdermal

A

diffuses by skin absorption

27
Q

What are the different from of transdermal

A

adhesive patch

percutaneous - creams/ointments

28
Q

What is the advantage of transdermal

A

By pass first pass metabolism

controlled level of drugs

29
Q

Example of transdermal adhesive patches

A

HRT
Contraception
Nicotine
Opiates

30
Q

What is an example of a local and systemic percutaneous

A

local - steroid

systemic - HRT

31
Q

What is the advantages of inhalation

A

delivered directly to the lungs
rapid
little systemic absorption
reduced adverse reactions

32
Q

What are different methods of carrier based drug delivery

A

monoclomal antibodies
Liposomal drug delivery
Nanoparticle based drug delivery
Genetic transfer system

33
Q

What is the purpose of monoclonal antibodies

A

bind to cancer specific antigen and induce immune response to cancer cells

34
Q

what is the advantaged of Liposomal drug delivery

A

reduced toxicity

enhanced efficiency

35
Q

What is the advantage of nanotechnology

A

target precise location
therefore: more effective, specific
Reduce toxicity

36
Q

what are nanoerythrosomes

A

resealed erythrocytes that carry proteins, enzymes and macromolecules

37
Q

what can nanoerythrosomes treat

A

liver disease
parasitic infection
enzyme disease

38
Q

What is genetic transfer

A

When viral replication is implicated and used for good

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