Antimicrobial therapy - anti-viral drugs Flashcards Preview

Medicine Term One > Antimicrobial therapy - anti-viral drugs > Flashcards

Flashcards in Antimicrobial therapy - anti-viral drugs Deck (28):
1

What does it means that all anti viral drugs are virustatic

inhibit growth/ replication

2

Give examples of Herpes viruses

Herbes simple virus
Varicella zoster virus
Epstein-barr virus
cytomegalovirus

3

What is an antiviral that is active against both HSV and VZV

aciclovir

4

How is aciclovir activated

Converted to active from by an enzyme (thymidine kinase) coded for by the virus genome

5

What is the benefits of aciclovir being activated by virus genome

Specific for virus infected cells
Low toxicity for unaffected cells

6

What do you do with acyclovir in patients with renal impairment

lower the does

7

What antiviral drugs are used in the treatment of HSV and shingles instead of aciclovor and why

famciclovir and valaciclovir
better bioavailability

8

ganciclovir is active against what herpes virus

cytomegalovirus
toxic given by IV fusion

9

What is valganciclovir

prodrug of ganciclovir oral alternative

10

What needs to be moniitored with valganciclovir and ganciclovir

Blood count for bone marrow toxicity

11

When is foscarentt used

Used for some HSV, VZV and CMV infections when the infection is resistant to other antifungals

12

What are features of fosxarent

Highly nephrotoxic and is only given by IV

13

When is Cidofovir used

for CMV when other anti fungals are inappropriate

14

Name all the different anti herpes virus drugs

Aciclovir - HSV/ VZV
Famciclovir and Valaciclovir - HSV and shingles (stronger)
ganciclovir CMV (IV)
valganciclovir CMV (oral)
foscarnet HSV VSV CMV (IV) (last resort)
cidofovir - CMV (last resort)

15

What is a nucleoside analogue

interfere with the action of the reverse transcription

16

What therapy is used for HIV

Combination therapy of at least two drugs which are active on different stages of HIV replication

17

What inhibitors can be used in therapy of HIV

Two nucleoside analogue reverse transcriptase inhibitors
plus non-nucleoside reverse transcriptase inhibitors
or a Protese inhibitor

18

How is HIV therapy monitored

viral load and CD4+ cell count

19

What is used to treat chronic hepatitis B and C

Interferon alpha
Lamivudine - hep B
Ribavain

20

What is the advantage of interferon alpha

taken orally

21

What is lamivudine mainly used to treat

HIV treatment and Hep B

22

Zanamavir and oseltamivir are both used in the treatment of what

Influenza within 48 hours of symptoms or as prophalaxis

23

What nucleoside analogue can be used for the treatment of respiratory syncytial virus

Ribavarin

24

What is genotypic analysis

sequencing of part of viral genome

25

What is drug monitoring for in antiviral therapy

ensure therapeutic index

26

What antiviral drugs can be monitored

some anti HIV drugs and aciclovir

27

What is an anti HIV for nucleoside analogue

Zidovudine

28

In Ant- HIV what is the non-nucleoside reverse transcriptase inhibitors or the Protese inhibitor that is used in combination with zidovudine

non-nucleoside reverse transcriptase inhibitors - nevirapine
Protease inhibitor -saquinavir

Decks in Medicine Term One Class (59):