What can fungus be subdivided into
Yeats and filamentous fungi (moulds)
What is the combined form of fungus called
dimorphic fungi
What are the different classes of anti fungal drugs
Polyenes
Azoles
Allyamines
Echinocandins
How do polyenes increase the permeability of the cell wall
Bind to ergosterol in fungi cell wall
What is the reason for polyenes toxicity
also bind to other sterols (cholesterol) in mammalian cells
What are two examples of polyenes anti fungal drugs
amphotericin B
Nystatin
Is amphotericin toxic?
yes
What polyenes anti fungal drug can be available for IV use
amphotericin B
How is nystatin available
topic use (creams, oral, pessaries)
How do azoles work as an anti fungal
inhibit ergosterol synthesis
How are azoles subdivided
Imidazoles
triazoles
Name two imidazoles
miconazole
ketoconazole
Give three examples of triazoles
flucanozole
itraconazole
voriconazole
How is flucaozole given and what is it active against
used for oral and parenteral treatment of yeast infections
What is itraconazole active against
Yeast and filamentous fungi
What can treat aspergillosis
voriconazole and itraconazole
What is building a resistance to fluconazole
resistance among some candida species
How do allylamines work as anti fungals
suppress ergosterol synthesis
what is an example of an allylamine anti fungal
terbinafine
What is terabinafine primarily active against and its clinical use
dermatophytes
dermatophyte infections of the skin and nails e.g. athletes foot
How does echinocandins work as an anti fungal
inhibit the synthesis of glucan polysaccharide
What are the three echinocandins
caspofungin
mycafungin
andiulafungin
What are ecinocandins used for
serious aspergillus and candida infections
