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Flashcards in Viral pathogenic mechanism Deck (21)
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1
Q

What are the sites of viral entry

A
conjuntivia 
capillary 
skin
digestive tract 
respiratory tract
2
Q

Latent infection

A

Virus that lies dormant then is triggered and returns

3
Q

Example of latent infection

A

Herpes simplex virus:
cold sores
genital lesions

4
Q

example of an acute virus infection

A

Influenza a virus - respiratory infection
neurological infections -
Enteric infections - occur in intestine

5
Q

What can viral infections become

A

bacterial

6
Q

What is viaremia

A

Virus going into the blood

7
Q

Where are acute viral infections localised

A

to specific part of the body

8
Q

What happens in influenza viral infection

A

Destruction of respiratory epithelium

Altered cytokine expression leading to fever

9
Q

Where is enterovirus excreted

A

faeces

10
Q

Development of Viraremia is bad because

A

causes widespread infection of tissues and if enters neuronal tissue causes paralysis

11
Q

What is antigenic drift

A

Gradual evolution of viruses to generate antigenic variants

12
Q

Generation of novel influenza viruses due to

A

antigenic drift

antigenic shift

13
Q

what is antigenic shift

A

Significant changes in virus antigenic structure

14
Q

What plays a main role in antigenic shift for influenza virus

A

confection with nonhuman hosts
eg avain virus - bird flu
swine influenza

15
Q

What is a enterovirus

A

any of a group of RNA viruses which typically occur in the gastrointestinal tract, sometimes spreading to the central nervous system or other parts of the body.

16
Q

What is examples of enterovirus

A

Poliomyelitis (poliovirus) - paralysis
Meningitis - meniges to much
Myocarditis (inflammation of the heart muscle) Pancreatitis - inflammation of the pancrease

17
Q

What diseases does coxsackie B viruses cause

A

Pancreatitis

Myocarditis

18
Q

What does poliovirus result in if become neurological

A

muscle weakness, leading to paralysis

19
Q

In Herpes viral latent infection where does the virus migrate to and remains

A

migrates to ganglia

and remains latent in the nucleus

20
Q

give two examples of viral induced tumours

A

Papillomaviruses – cervical cancer
Retroviruses – lymphomas (cancer of the lymph nodes)
-leukaemias (decreased WBC)

21
Q

What does a retro virus do

A

modifies host cells gene expression using trans-activating protein resulting in tumour formation

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